Hybrid approaches to tissue engineering

组织工程的混合方法

• 批准号: EP/I020861/1
• 负责人: Julian Jones
• 金额: $ 129.71万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI020861%2F1
• 关键词: Hybrid; approaches; tissue; engineering

Our life expectancy is increasing and we are outliving our skeletal tissues. There is a need for orthopaedic surgery to move from replacement of tissues to regeneration. To do this medical devices are required that can stimulate the body's own healing mechanisms. Over the last 10-15 years, tissue engineering has promised that combining engineering principles with cells will lead to regeneration of tissues, however skin is the only tissue engineered product used clinically. The reasons skeletal tissue engineering has not been successful is that materials have not been developed that fulfill all the engineering design criteria for regenerative device (scaffold) and how materials interact with cells is not fully understood. A new hybrid approach is proposed where hybrid refers to an integrated interdisciplinary approach and the innovation in materials engineering that is needed. New materials must be developed that mimic the mechanical properties and structure of natural tissues. The aim is to build an interdisciplinary research team that can deliver high impact step changes in the way tissue engineering research is carried out to make skeletal tissue engineering a clinical reality. Team members will have expertise in materials chemistry and processing, multi-scale characterisation, materials modelling, cell biology, orthopaedic surgery and technology transfer. The adventurous programme will benefit the UK by improving the quality of life of patients, increasing the efficiency of orthopaedic surgery, reducing surgical costs and boosting the UK economy by ensuring patients recover and return to work more rapidly.The core platform technology will be novel nanostructured (hybrid) materials that can be designed to stimulate bone growth or cartilage regeneration before they are remodelled in the body and replaced by natural healthy tissue. To make these complex materials a clinical reality they must be understood from the atomic through the nano to the macro level and optimised with respect to cellular response. Computer models and improved characterisation methods are needed. Bone scaffolds must stimulate stem cells to produce bone and new ways of growing cells in devices may be necessary in order for blood vessels to grow throughout bone scaffolds and for cartilage regeneration to become a reality. If new devices are to reach the clinic, technology transfer must be considered. My vision is to build and lead a world renowned research group successful in musculoskeletal tissue engineering with a new field of inorganic/ organic hybrid materials engineering at its core. The research group will attract best, internationally leading researchers to the UK (or to stay in the UK). It will involve international and UK collaborators, with the UK at the focus, placing it at the forefront of biomaterials and tissue engineering. There will be focus on developing a dynamic and supportive research environment and on developing the career of group members so they will become the next leaders of the new fields that will evolve from the group's work.

我们的预期寿命在增加，我们的寿命超过了骨骼组织。骨科手术需要从组织替换转向组织再生。要做到这一点，需要能够刺激身体自身愈合机制的医疗设备。在过去的10-15年里，组织工程已经承诺将工程原理与细胞相结合将导致组织再生，但皮肤是临床上使用的唯一组织工程产品。骨骼组织工程尚未成功的原因是尚未开发出满足再生装置（支架）的所有工程设计标准的材料，并且材料如何与细胞相互作用尚未完全了解。提出了一种新的混合方法，其中混合是指一个综合的跨学科的方法和创新的材料工程是必要的。必须开发新的材料，模仿自然组织的机械性能和结构。其目的是建立一个跨学科的研究团队，可以提供高影响力的步骤变化的方式进行组织工程研究，使骨骼组织工程的临床现实。团队成员将拥有材料化学和加工、多尺度表征、材料建模、细胞生物学、骨科手术和技术转让方面的专业知识。这项冒险的计划将通过改善患者的生活质量，提高骨科手术的效率，通过确保患者更快地康复和重返工作岗位，降低手术成本，促进英国经济发展。核心平台技术将是新型纳米结构（混合）这些材料可以被设计成在它们在体内重塑并被天然健康组织取代之前刺激骨骼生长或软骨再生。为了使这些复杂的材料成为临床现实，必须从原子到纳米到宏观层面进行理解，并根据细胞反应进行优化。需要计算机模型和改进的表征方法。骨支架必须刺激干细胞产生骨，并且为了使血管在整个骨支架中生长和软骨再生成为现实，在设备中生长细胞的新方法可能是必要的。如果新设备要进入临床，必须考虑技术转让。我的愿景是建立和领导一个世界知名的研究小组，成功地在肌肉骨骼组织工程与无机/有机杂化材料工程的新领域为核心。该研究小组将吸引最好的，国际领先的研究人员到英国（或留在英国）。它将涉及国际和英国的合作者，重点是英国，使其处于生物材料和组织工程的最前沿。将重点发展一个充满活力和支持性的研究环境，并发展小组成员的职业生涯，使他们成为新领域的下一个领导者，这些领域将从小组的工作中发展出来。

项目成果

Preparation of electrospun poly(lactic acid)-based hybrids containing siloxane-doped vaterite particles for bone regeneration.

用于骨再生的含有硅氧烷掺杂的球霰石颗粒的电纺聚乳酸基杂化物的制备。

• DOI: 10.1163/092050611x582867
• 发表时间: 2012
• 期刊: Journal of biomaterials science. Polymer edition
• 作者: Fujikura K

Transesterification of functional methacrylate monomers during alcoholic copper-catalyzed atom transfer radical polymerization: formation of compositional and architectural side products

• DOI: 10.1039/c2py20280h
• 发表时间: 2012-08
• 期刊: Polymer Chemistry
• 影响因子: 4.6
• 作者: Louise S. Connell;Julian R. Jones;J. Weaver