PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

这是一项纵向项目(纵向项目)的五年续展建议 纽约高危项目)对精神分裂症、抑郁症或 自1971年以来，这项工作一直在进行。的主要目标 Sutdy一直关注于确定一种 易患精神分裂症或精神分裂症谱系 精神错乱。在本赠款期间，该项目扩大到 包括被研究儿童以前没有被研究过的兄弟姐妹，以及更多 关注父母，这些额外的科目将继续 在更新的岁月里学习。 在拟议的更新期间，所有科目都将作为 成年人，主要目标是：(1)评估早期阶段的 第一次经历(或最近经历)的受试者的疾病 精神障碍的发作；(2)继续审视 精神分裂症谱系，使用我们的样本试图定义标准 对精神分裂症患者亲属具有较高的敏感性和特异性 先证者；(3)继续学习注意和信息加工 (AIP)措施和顺畅追踪眼球运动(SPEM)涉及： 他们预测成人精神障碍的准确性，他们的 精神分裂症和相关疾病的特异性，状态-特质问题， 和家庭聚类法；(4)更新所有家庭的诊断评估 成员；(5)进行多项与以下项目有关的基因分析 不同的风险估计，以及遗传力和家族分离 AIP和SPEM的临床特点和测量方法；(6)采血 保存精神分裂症父母家庭DNA的样本。 此外，我们希望研究可能的缓冲和压力源。

This is a proposal for a five-year renewal of a longitudinal project (the New York High-Risk Project) on children of schizophrenic, depressed or normal parents, which has been ongoing since 1971. Major goals of the sutdy have been concerned with the identification of early indicators of a liability to the development of schizophrenia or schizophrenis spectrum disorders. In the current grant period, the project was extended to include previuosly-not-studied siblings of the study children, and greater focus on the parents, and these additional subjects will continue to be studied in the renewal years. In the proposed renewal period, in which all subjects will be studied as adults, major goals are concerned with: (1) assessing early stages of illness in subjects who experience (or have recently experienced) a first episode of psychiatric disorder; (2) continuing to examine the concept of the schizophrenia spectrum, using our samples to attempt to define criteria with high sensitivity and specificity for relatives of schizophrenic probands; (3) continuing to study attentional and information processing (AIP) measures and smooth pursuit eye movements (SPEM) with respect to: the accuracy with which they predict to adult psychiatric disorders, their specificity for schizophrenia and related disorders, state-trait questions, and familial clustering; (4) updating diagnostic assessments on all family members; (5) carrying out a number of genetic analyses relating to differential risk estimates, and heritabilities and familial segregation of clinical features and of AIP and SPEM measures; (6) collecting blood samples to preserve DNA in the families of schizophrenic parents. Additionally, we hope to study possible buffers and stressors.