PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

这是一个纵向项目（ 纽约高风险项目）的儿童精神分裂症，抑郁症或 自1971年以来一直在进行的正常父母。 大目标 研究一直关注的是确定早期指标， 易患精神分裂症或精神分裂症谱系 紊乱 在目前的赠款期间，该项目已扩展到 包括以前未研究过的研究儿童的兄弟姐妹，以及更大的 关注父母，这些额外的科目将继续 在更新的岁月里学习。 在建议的更新期内，所有科目将作为 成人，主要目标是：（1）评估早期阶段的 经历（或最近经历）第一次 精神障碍发作;（2）继续检查的概念， 精神分裂症谱，使用我们的样本，试图定义标准， 对精神分裂症患者亲属有较高的敏感性和特异性 先证者;（3）继续研究注意和信息加工 (AIP)测量和平滑追踪眼球运动（SPEM）： 他们预测成人精神疾病的准确性， 精神分裂症和相关疾病的特异性，状态-特质问题， 和家庭聚集性;（4）更新所有家庭的诊断评估 （5）进行一系列的基因分析， 不同的风险估计，遗传性和家庭隔离， 临床特征及AIP和SPEM测量;（6）采集血液 样本来保存精神分裂症父母家庭的DNA。 此外，我们希望研究可能的缓冲和压力。

This is a proposal for a five-year renewal of a longitudinal project (the New York High-Risk Project) on children of schizophrenic, depressed or normal parents, which has been ongoing since 1971. Major goals of the sutdy have been concerned with the identification of early indicators of a liability to the development of schizophrenia or schizophrenis spectrum disorders. In the current grant period, the project was extended to include previuosly-not-studied siblings of the study children, and greater focus on the parents, and these additional subjects will continue to be studied in the renewal years. In the proposed renewal period, in which all subjects will be studied as adults, major goals are concerned with: (1) assessing early stages of illness in subjects who experience (or have recently experienced) a first episode of psychiatric disorder; (2) continuing to examine the concept of the schizophrenia spectrum, using our samples to attempt to define criteria with high sensitivity and specificity for relatives of schizophrenic probands; (3) continuing to study attentional and information processing (AIP) measures and smooth pursuit eye movements (SPEM) with respect to: the accuracy with which they predict to adult psychiatric disorders, their specificity for schizophrenia and related disorders, state-trait questions, and familial clustering; (4) updating diagnostic assessments on all family members; (5) carrying out a number of genetic analyses relating to differential risk estimates, and heritabilities and familial segregation of clinical features and of AIP and SPEM measures; (6) collecting blood samples to preserve DNA in the families of schizophrenic parents. Additionally, we hope to study possible buffers and stressors.