A PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

描述：(由申请人提供)：NYHRP的这一最后阶段将集中于通过以下方式有序地完成这项纵向研究：1)准备并将NYHRP从1971年开始到2005年完成的整个数据库放在一个档案储存库中，目的是共享数据；2)进行汇报电话，向NYHRP一直保持定期年度联系的600多名参与者(父母、目标、兄弟姐妹)中的每一个人道别，并在电话之后附上一封信，附上NYHRP社会工作者已经习惯于提供的转介和其他援助的资源清单。此外，还将实现目前处于中期阶段的三个剩余目标。这些是：3)完成将RDC的初步诊断转换为DSM-IV诊断的所有参与者的初步诊断；共病疾病也将转换为DSM-IV诊断；4)完成从选定的家庭采集血液或口腔拭子样本，以提取和保存DNA，以供未来研究使用；5)完成手稿，准备作为同行审查的出版物提交。

DESCRIPTION: (provided by applicant): This final phase of the NYHRP will focus on bringing this longitudinal study to an orderly conclusion by 1) preparing and placing in an archival respository the entire databank of the NYHRP from its start in 1971 to its completion in 2005, for the purpose of data sharing and 2) carrying out debriefing telephone calls to say good bye to each of the 600+ participants (parents, Targets, Siblings) with whom the NYHRP has been in regular annual contact and following the calls with a letter accompanied by a list of resources for referrals and other assistance that the NYHRP social workers have been accustomed to provide. Additionally, three remaining goals that are now in midprocess will be carried out. These are: 3) completion of the translation (rediagnosis) of RDC to DSM-IV diagnoses for all participants who have received Axis I as primary diagnosis; comorbid disorders will also be translated to DSM-IV; 4) completion of the collection of blood or buccal swab samples from selected families for extraction and preservation of DNA for probable use in future studies; 5) completion of manuscripts in preparation for submission as peer-reviewed publications.