PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

这是一项关于纵向计划的三年续展的建议 针对患有精神分裂症、抑郁症或父母正常的儿童的项目 自1971年以来一直在进行。这项研究的主要目标是 确定与发展有关的负债的早期指标 精神分裂症或精神分裂症谱系障碍或情感障碍。 两个独立的样本，每个样本由几组有患病风险的儿童组成 这些障碍和精神疾病的低风险群体，正在 一直跟踪到受试者达到年轻成年期，以使 调查人员追踪受试者在一段时间内的发展情况 并将心理生物学(即注意力和信息)联系起来 加工、神经运动功能和心理生理学数据)和 从儿童时期研究的行为变量到 成人期。最近对样本A受试者进行了检查(第四次 时间)在成年早期。 计划对样本B进行第四轮检查 青年时期的受试者，与最近评估的样本相当 A.核心项目的另一个目标是完成对 在样本B的第三次检查中进行的精神病学面谈，至 从一个由三个独立成员组成的小组获得最终诊断评估 将审查关于盲人受试者的终身数据的法官 家长的诊断，并完成对通过 整个研究过程，包括纵向分析和 跨样本比较。 还提出了三个子项目；每个子项目将扩展数据 收集到样本A和样本B中主要受试者的家庭。 在L的子项目中，人格障碍访谈将与 受试者及其非精神病父母(患者的配偶或其父母 正常的比较对象)以澄清光谱的性质 精神错乱。在分项目2中，将进行家族史访谈 有尽可能多的家庭成员来完成所需的信息 基因分析。在分项目3中，主要科目的兄弟姐妹将是 给出的临床评估组件与对主要的 在他们的第四轮考试时的科目。

This is a proposal for a three-year renewal of a longitudinal program project on children of schizophrenic, depressed, or normal parents that has been ongoing since 1971. Major goals of the study have been concerned with the identification of early indicators of a liability to the development of schizophrenia or schizophrenia spectrum disorders or affective disorders. Two independent samples, each consisting of groups of children at risk for these disorders and a group at low risk for mental illness, are being followed until the subjects reach young adulthood to enable the investigators to trace the development of the subjects over a period of years and to relate psychobiological (i.e., attention and information processing, neuromotor functioning, and psychophysiological data) and behavioral variables studied in childhood to psychopathology emerging in adulthood. Sample A subjects have recently been examined (for the fourth time) in early adulthood. It is planned to conduct a fourth round of examinations on Sample B subjects in young adulthood, comparable to the recent assessment of Sample A. Further aims of the core project are to complete diagnostic ratings of psychiatric interviews conducted in the third examination of Sample B, to obtain final diagnostic assessments from a panel of three independent judges who will review lifetime data on the subjects blind with respect to parents' diagnoses, and to complete analyses of the data collected over the course of the entire study, including longitudinal analyses and cross-sample comparisons. Three subprojects are also proposed; each subproject will extend the data collection to the families of the main subjects in Sample A and Sample B. In Subproject l, personality disorder interviews will be conducted with the subjects and their nonpsychotic parents (spouses of patients or parents of the normal comparison subjects) to clarify the nature of spectrum disorders. In Subproject 2, family history interviews will be conducted with as many family members as possible to complete information needed for genetic analyses. In Subproject 3, siblings of the main subjects will be given the same clinical assessment battery as is administered to the main subjects at the time of their fourth round of examinations.