EPSRC-NIHR HTC Partnership Award 'Plus': Medical Devices and Vulnerable Skin: Intellegent sensing to promote self-management.

EPSRC-NIHR HTC 合作伙伴奖“Plus”：医疗设备和脆弱皮肤：促进自我管理的智能传感。

• 批准号: EP/N02723X/1
• 负责人: Daniel Bader
• 金额: $ 64.08万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN02723X%2F1
• 关键词: EPSRC; NIHR; HTC; Partnership; Award

Modern medicine has been transformed in recent decades, with advances leading to increased life expectancy and a significant number of individuals living with long term health conditions. This has, in part, been due to the development of advanced medical devices which provide a range of interventions, including respiratory support and mobility aids. Many of these devices have to interface with the body, which creates a mechanical force against the underlying skin and soft tissues. An individual ability to withstand these forces depends on the vulnerability of skin tissues, with factors such as age, vascularity and previous wounds contributing to their tolerance. Clinicians provide medical devices to match the patient needs at that time of fitting, ensuring the device is both functional and comfortable. Inevitably, circumstances and demands change with time for the individual, which can impair the effectiveness of the device and in some cases cause harm. Indeed, evidence has implicated medical devices in the development of over 30% of pressure ulcers acquired in hospitals. These pressure ulcers contribute to an NHS financial wound care burden of £4Bn/yr. Subsequently, many devices are discarded, thus compromising individual needs and costing the healthcare provider valuable resources.Medical Devices and Vulnerable Skin NetworkPlus (MDVSNplus) will integrate research expertise and motivate clinicians and industrialists to provide intelligent strategies to maintain medical device longevity and patient comfort in a range of clinical settings. It brings together leaders in the fields of sensing, imaging and computer simulation to provide the necessary expertise to evaluate the impact of new and existing medical devices which attach to vulnerable skin. We aim to use these capabilities to develop a series of intelligent mechanisms, for example sensors, which can monitor the functionality and safety of devices over time. MDVSNplus will also target methods of detecting when a device is causing harm to vulnerable skin and create an early warning system for patients and carers.MDVSNplus will encourage new research partners by offering funding for a series of feasibility projects which are aligned with our core aims. Each potential proposal will l be reviewed by an independent innovation panel and assessed based on the clinical need and feasibility to translate the research findings to practice. Funding to the MDVSNplus will also be used to host outreach events for clinicians and end users in order to provide evidence based guidance and education on the choice and application of medical devices. The MDVSNplus will also work closely with colleagues based in the healthcare sector, who specialise in medical devices and wound prevention, to bridge the gap between research findings and the application into clinical practice.Through these funded projects the MDVSNplus will provide innovation to improve quality of life in individuals who depend on the use of medical devices. This will also offer the opportunity for the NHS to reduce costs associated with treatment of medical-device related skin damage and their potential recurrence. It will also ensure that devices which are current being supplied can be optimised in terms of functionality and longevity, providing the best value for money. We also envisage that new medical devices and sensing technologies will attract interest from the healthcare industry to reinvest in novel medical device technologies. In order to sustain the impact of the research findings the applicants will lobby key agencies such as the MHRA (UK medical device regulator), to raise the awareness of medical device related injuries and inform legislation surrounding device design and application. Research output from the MDVSNplus will also contribute to clinical guidelines surrounding the application of medical devices and, where necessary, new standards of medical device testing.

近几十年来，现代医学发生了变化，进步导致预期寿命延长，许多人生活在长期健康状况中。这在一定程度上是由于先进医疗设备的发展，这些设备提供了一系列干预措施，包括呼吸支持和行动辅助设备。这些设备中的许多都必须与身体连接，从而对底层的皮肤和软组织产生机械力。个人承受这些力量的能力取决于皮肤组织的脆弱性，年龄、血管状况和以前的伤口等因素有助于皮肤组织的耐受性。临床医生提供医疗设备，以满足患者在安装时的需求，确保设备既实用又舒适。不可避免地，环境和需求随着时间的推移而改变，这可能会损害设备的有效性，在某些情况下会造成伤害。事实上，有证据表明，医疗器械与30%以上在医院获得的压疮的发展有关。这些压力性溃疡导致NHS每年40亿英镑的财政伤口护理负担。随后，许多设备被丢弃，从而损害了个人需求并耗费了医疗保健提供者宝贵的资源。医疗设备和脆弱皮肤网络（MDVSNplus）将整合研究专业知识，并激励临床医生和实业家提供智能策略，以在一系列临床环境中保持医疗设备的使用寿命和患者舒适度。它汇集了传感、成像和计算机模拟领域的领导者，提供必要的专业知识，以评估附着在脆弱皮肤上的新型和现有医疗设备的影响。我们的目标是利用这些能力开发一系列智能机制，例如传感器，可以随着时间的推移监控设备的功能和安全性。MDVSNplus还将针对检测设备何时对脆弱的皮肤造成伤害的方法，并为患者和护理人员创建一个早期预警系统。MDVSNplus将通过为一系列符合我们核心目标的可行性项目提供资金来鼓励新的研究伙伴。每个潜在的提案将由一个独立的创新小组进行审查，并根据临床需要和将研究成果转化为实践的可行性进行评估。向MDVSNplus提供的资金还将用于为临床医生和最终用户举办外联活动，以便就医疗装置的选择和应用提供基于证据的指导和教育。MDVSNplus还将与医疗保健部门的同事密切合作，他们专门研究医疗设备和伤口预防，以弥合研究成果与临床实践应用之间的差距。通过这些资助项目，MDVSNplus将提供创新，以改善依赖医疗设备使用的个人的生活质量。这也将为NHS提供机会，降低与医疗器械相关的皮肤损伤及其潜在复发治疗相关的费用。它还将确保目前供应的设备可以在功能和寿命方面进行优化，从而提供最佳的物有所值。我们还设想，新的医疗设备和传感技术将吸引医疗保健行业的兴趣，以重新投资新的医疗设备技术。为了维持研究结果的影响，申请人将游说主要机构，如MHRA（英国医疗器械监管机构），以提高对医疗器械相关伤害的认识，并告知有关器械设计和应用的立法。MDVSNplus的研究成果还将有助于制定有关医疗装置应用的临床准则，并在必要时制定医疗装置测试的新标准。

项目成果

Changes in Tissue Composition and Load Response After Transtibial Amputation Indicate Biomechanical Adaptation.

• DOI: 10.1007/s10439-021-02858-0
• 发表时间: 2021-12
• 期刊: Annals of biomedical engineering
• 影响因子: 3.8
• 作者: Bramley JL;Worsley PR;Bader DL;Everitt C;Darekar A;King L;Dickinson AS
• 通讯作者: Dickinson AS

Changes in tissue composition and load response after transtibial amputation indicate biomechanical adaptation

经胫骨截肢后组织成分和负荷反应的变化表明生物力学适应

• DOI: 10.31224/osf.io/b3y4h
• 发表时间: 2021
• 作者: Bramley J

Technologies to monitor the health of loaded skin tissues.

• DOI: 10.1186/s12938-018-0470-z
• 发表时间: 2018-04-12
• 期刊: Biomedical engineering online
• 影响因子: 3.9
• 作者: Bader DL;Worsley PR
• 通讯作者: Worsley PR

Personal protective equipment related skin reactions in healthcare professionals during COVID-19.

• DOI: 10.1111/iwj.13534
• 发表时间: 2021-06
• 期刊: International wound journal
• 影响因子: 3.1
• 作者: Abiakam N;Worsley P;Jayabal H;Mitchell K;Jones M;Fletcher J;Spratt F;Bader D
• 通讯作者: Bader D

Detection of posture and mobility in individuals at risk of developing pressure ulcers

• DOI: 10.1016/j.medengphy.2021.03.006
• 发表时间: 2021-04-05
• 期刊: MEDICAL ENGINEERING & PHYSICS
• 影响因子: 2.2
• 作者: Caggiari, Silvia;Worsley, Peter R.;Bader, Dan L.
• 通讯作者: Bader, Dan L.