EPSRC-NIHR HTC Partnership Award 'Plus': IMPRESS

EPSRC-NIHR HTC 合作伙伴奖“Plus”：IMPRESS

• 批准号: EP/N027345/1
• 负责人: Peter Culmer
• 金额: $ 64.34万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN027345%2F1
• 关键词: EPSRC; NIHR; HTC; Partnership; Award

IMPRESSPlus has been designed to maximise and extend the impact of the current IMPRESS network by applying engineering sciences to deliver novel solutions to the many challenges that exist in the management and treatment of incontinence. There is a critical lack of scientific research in this area compared to areas such as vascular, cardiac and orthopaedic healthcare - each of which have shown huge gains through the application of focussed basic and translational science.Faecal Incontinence (FI) is defined as the inability to fully control the passage of faeces through the anus. This may arise due to a weakened anal sphincter muscle (typically following child birth), problems with nerve supply (e.g. stroke, multiple sclerosis), or in association with other gastrointestinal conditions (e.g. irritable bowel syndrome). It is a common and distressing condition that causes shame, embarrassment, depression, social isolation, secrecy, poor self-esteem, and sexual avoidance. As a result, more than 54% of patients with FI have not discussed their symptoms with a physician , and only one-quarter of patients with FI are referred by their GP for specialist treatment . Its exact prevalence is difficult to determine but best estimates suggest that in the adult population it is around 10%, and that 0.5% - 1% below 65 years and 3% - 8% over 65 years' experience regular faecal incontinence. Urinary Incontinence (UI) is defined as involuntary leakage of urine, UI presents a major burden on NHS resources. It is a common and distressing condition, which impacts of quality of life. The main forms of UI are stress incontinence (SUI), which is leakage with physical exertion, and urge incontinence (UUI), which is leakage with a strong desire to void. Mixed urinary incontinence is a combination of SUI and UUI. The prevalence of UI increases with age and is higher in institutionalised adults, who tend to be older and suffer associated co-morbidity. It is more often a problem for females, with prevalence rates of UI ranging from 4.5% to 53% in women, as compared to 1.5% and 24% in men. Although previously considered in isolation, it is increasingly recognised that many forms of FI and UI share a common underlying pathophysiology and frequently co-exist with pelvic organ prolapse.Incontinence places a massive burden on the NHS and impacts significantly on quality of life for thousands of patients in the UK. Whilst many areas of medical engineering share a growth in the engagement of engineers and scientists to push forward the exploitation of emerging technologies it is arguably the case that the nature of this disease prevents engineering and science research leaders seeing the potential for some rich research challenges. To date the IMPRESS network has been successful in fulfilling its objectives of increasing the number of leading UK technologists (from academia and industry) that are engaged with research into the clinical changes associated with incontinence. This is demonstrated through a range of exciting new collaborative projects that have arisen from IMPRESS workshops and events and have been supported by competitive pump-priming funding from the network. IMPRESSPlus will secure the legacy of the existing IMPRESS network. This will be achieved by:1) strategically supporting emerging research with feasibility project funding 2) running international IMPRESSPlus conference workshops to build the network3) using a researcher secondment scheme to aid knowledge-transfer with industry and leading international research centres4) disseminating the networks findings to researchers, patients, healthcare providers and policy makers5) identifying long-term funding for the network and its researchIn summary, through the IMPRESS network we aim to resolve the current impasse that stifles innovation and translation of new engineering technologies for the management, treatment and prevention of incontinence.

IMPRESSPlus旨在通过应用工程科学为失禁管理和治疗中存在的许多挑战提供新的解决方案，从而最大限度地发挥和扩大当前IMPRESS网络的影响。与血管、心脏和整形外科医疗保健等领域相比，这一领域的科学研究严重缺乏，而这些领域都通过集中的基础和转化科学的应用取得了巨大的进展。粪便失禁（FI）的定义是无法完全控制粪便通过肛门。这可能是由于肛门括约肌减弱（通常在分娩后），神经供应问题（例如中风，多发性硬化症）或与其他胃肠道疾病（例如肠易激综合征）有关。这是一种常见且令人痛苦的情况，会导致羞耻，尴尬，抑郁，社会孤立，保密，自尊心差和性回避。因此，超过54%的FI患者没有与医生讨论他们的症状，只有四分之一的FI患者被他们的GP转介接受专家治疗。它的确切患病率很难确定，但最佳估计表明，在成年人群中，它约为10%，65岁以下的0.5% - 1%和65岁以上的3% - 8%经历定期大便失禁。尿失禁（UI）被定义为尿液的非自愿泄漏，UI是NHS资源的主要负担。这是一种常见而令人痛苦的疾病，影响生活质量。尿失禁的主要形式是压力性尿失禁（SUI），即体力消耗导致的渗漏，以及急迫性尿失禁（UUI），即强烈排尿欲望导致的渗漏。混合性尿失禁是SUI和UUI的组合。UI的患病率随着年龄的增长而增加，在机构化的成年人中更高，他们往往年龄较大，患有相关的合并症。这通常是女性的问题，女性的UI患病率为4.5%至53%，而男性为1.5%和24%。虽然以前被认为是孤立的，它越来越多地认识到，许多形式的FI和UI共享一个共同的潜在病理生理学，并经常与盆腔器官脱垂共存，inflammatory地方NHS的巨大负担，并影响生活质量的数千名患者在英国。虽然医学工程的许多领域都有越来越多的工程师和科学家参与推动新兴技术的开发，但可以说这种疾病的性质阻止了工程和科学研究领导者看到一些丰富的研究挑战的潜力。到目前为止，IMPRESS网络已经成功地实现了增加英国领先技术专家（来自学术界和工业界）的数量的目标，这些技术专家参与了与失禁相关的临床变化的研究。这一点通过一系列令人兴奋的新合作项目得到了证明，这些项目来自IMPRESS研讨会和活动，并得到了网络竞争性泵启动资金的支持。IMPRESSPlus将保护现有IMPRESS网络的遗产。这将通过以下方式实现：1）通过可行性项目资金战略性地支持新兴研究2）举办国际IMPRESSPlus会议研讨会以建立网络3）使用研究人员借调计划来帮助与行业和领先的国际研究中心进行知识转移4）将网络研究结果传播给研究人员，患者，医疗保健提供者和政策制定者5）为网络及其研究确定长期资金总之，通过IMPRESS网络，我们旨在解决目前的僵局，这种僵局扼杀了用于管理，治疗和预防失禁的新工程技术的创新和转化。

项目成果

Suppression of Urinary Voiding by Conditional High Frequency Stimulation of the Pelvic Nerve in Conscious Rats.

• DOI: 10.3389/fphys.2018.00437
• 发表时间: 2018
• 期刊: Frontiers in physiology
• 影响因子: 4
• 作者: Brouillard CBJ;Crook JJ;Irazoqui PP;Lovick TA
• 通讯作者: Lovick TA

High Frequency Stimulation of the Pelvic Nerve Inhibits Urinary Voiding in Anesthetized Rats.

• DOI: 10.3389/fphys.2017.00623
• 发表时间: 2017
• 期刊: Frontiers in physiology
• 影响因子: 4
• 作者: Crook JJ;Lovick TA
• 通讯作者: Lovick TA

How normalisation factors influence the interpretations of 3D-printed sensors for electroanalysis

• DOI: 10.1016/j.jelechem.2020.114937
• 发表时间: 2021-01-15
• 期刊: JOURNAL OF ELECTROANALYTICAL CHEMISTRY
• 影响因子: 4.5
• 作者: Abdalla, Aya;Perez, Fernando;Patel, Bhavik Anil
• 通讯作者: Patel, Bhavik Anil

Continence technologies whitepaper: Informing new engineering science research.

失禁技术白皮书：为新的工程科学研究提供信息。

• DOI: 10.1177/0954411918784073
• 发表时间: 2019
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Culmer P

The effects of printing orientation on the electrochemical behaviour of 3D printed acrylonitrile butadiene styrene (ABS)/carbon black electrodes.

• DOI: 10.1038/s41598-018-27188-5
• 发表时间: 2018-06-14
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Bin Hamzah HH;Keattch O;Covill D;Patel BA
• 通讯作者: Patel BA