MODULATION OF BARORECEPTOR REFLEXES
压力感受器反射的调节
基本信息
- 批准号:3485826
- 负责人:
- 金额:$ 14.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1979
- 资助国家:美国
- 起止时间:1979-12-01 至 1997-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Using direct intraneural recordings (microneurography), I propose
to extend my research on factors that modulate reflex control of
muscle sympathetic nerve activity (MSNA) in humans including
mental stress, somatic afferents and physical conditioning.
Unique features of the work include use of microneurography to
study 1) differential control of MSNA to arm and leg by
cardiopulmonary and cutaneous afferents and 2) modulation of
central neural sympathetic outflow during reflex stimuli such as
mental stress and baroreceptor activation. I plan to evaluate
these control mechanisms in normal subjects and to determine if
alterations in these mechanisms contribute to abnormal reflex
control in human hypertensives.
First, studies are proposed to test the hypothesis that sustained
stimulation of arterial baroreceptors is followed by an extended
period of inhibition of MSNA even after arterial pressure has
returned to control.
Second, I will employ simultaneous recordings of MSNA from
radial and peroneal nerves to test the hypothesis that
cardiopulmonary baroreflexes produce differential control of
MSNA to arm and leg.
Third, we have obtained preliminary evidence for segmental
activation of MSNA during somatic afferent stimulation in normal
humans. These observations are intriguing in view of the concept
that spinal reflexes are normally inhibited by supraspinal
mechanisms. I plan simultaneous recordings from radial and
peroneal nerves to test the hypothesis that cutaneous afferent
stimulation (cold pressor test) produces segmental as well as
generalized increases in MSNA in intact humans.
Fourth, we have recently demonstrated that mental stress
increases MSNA in the leg in humans. I plan to test the
hypothesis that endogenous opioids inhibit and beta adrenergic
mechanisms facilitate increases in central neural sympathetic
outflow during mental stress.
Fifth, our recent work suggests that activation of chemically
sensitive muscle afferents by muscle ischemia is the principal
stimulus to MSNA during exercise. Physical conditioning
minimizes muscle ischemia. I therefore intend to test the
hypothesis that physical conditioning will attenuate MSNA
responses to exercise.
Microneurographic recordings of MSNA are safe and provide a
substantial advance for studies of reflex control in humans.
我建议使用直接的神经内记录(微神经摄影)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ALLYN L. MARK的其他文献
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{{ truncateString('ALLYN L. MARK', 18)}}的其他基金
Leptin Receptor Signaling and Regulation of Sympathetic and Cardiovascular Funct
瘦素受体信号传导以及交感神经和心血管功能的调节
- 批准号:
7249784 - 财政年份:2007
- 资助金额:
$ 14.13万 - 项目类别:
Sympathetic and vascular control in genetic obesity
遗传性肥胖的交感神经和血管控制
- 批准号:
6843767 - 财政年份:2004
- 资助金额:
$ 14.13万 - 项目类别:
Mentored Clinical Research Scholar Program at Iowa
爱荷华州指导临床研究学者计划
- 批准号:
6788132 - 财政年份:2003
- 资助金额:
$ 14.13万 - 项目类别:
Mentored Clinical Research Scholar Program at Iowa
爱荷华州指导临床研究学者计划
- 批准号:
7119679 - 财政年份:2003
- 资助金额:
$ 14.13万 - 项目类别:
Mentored Clinical Research Scholar Program at Iowa
爱荷华州指导临床研究学者计划
- 批准号:
6941183 - 财政年份:2003
- 资助金额:
$ 14.13万 - 项目类别:
Mentored Clinical Research Scholar Program at Iowa
爱荷华州指导临床研究学者计划
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6571601 - 财政年份:2003
- 资助金额:
$ 14.13万 - 项目类别:
Mentored Clinical Research Scholar Program at Iowa
爱荷华州指导临床研究学者计划
- 批准号:
7260486 - 财政年份:2003
- 资助金额:
$ 14.13万 - 项目类别:
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