IMMUNOSENSOR FOR DRUG MONITORING

用于药物监测的免疫传感器

• 批准号: 3494383
• 负责人: WILLIFRIED SCHRAMM
• 金额: $ 4.95万
• 依托单位: PACIFIC BIOMETRICS, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-01 至 1990-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3494383
• 关键词: biosensor device; body fluids; cocaine; diagnosis design /evaluation; drug abuse; drug screening /evaluation; electrochemistry; human tissue; immunochemistry; immunologic assay /test; immunologic techniques; rapid diagnosis

For the efficient screening of drugs of abuse, simple but unambiguous analytical methods are required which can be performed on-site. This project is designed to develop an immunosensor for the detection of drugs of abuse. While the feasibility studies will be performed with cocaine and its major metabolite, benzoylecgonine, the sensor can be adapted to substances for which antibodies are available, including therapeutic drugs and other physiologically active compounds. Operation of the immunosensor does not require the usual procedures associated with immunoassays such as pipetting, adding to reagents, manual separation, mixing and the like but just dipping the disposable sensor into the biological medium (urine, blood, saliva). The generated signal will be monitored with existing technology as used for the measurement of blood glucose. The minimal time period for completing the assay is estimated to be between 3 and 5 minutes without the requirement to stop a reaction for completion.

对于滥用药物的有效筛查，简单但明确 需要可在现场进行的分析方法。 这 项目旨在开发用于检测药物的免疫传感器 虐待 虽然可行性研究将与可卡因进行 和其主要代谢物苯甲酰芽子碱，所述传感器可适于 可获得抗体的物质，包括治疗药物 和其它生理活性化合物。 免疫传感器的操作 不需要与免疫测定相关的常规程序， 移液、加入试剂、手动分离、混合等， 只需将一次性传感器浸入生物介质（尿， 血液、唾液）。 所产生的信号将通过现有的 用于测量血糖的技术。 的最小时间 完成测定的时间估计为3 - 5分钟 而不需要停止反应以完成。