PULSED SOLID-STATE LASER SOURCE FOR PHOTODYNAMIC THERAPY

用于光动力治疗的脉冲固态激光源

• 批准号: 3492881
• 负责人: PETER F MOULTON
• 金额: $ 4.96万
• 依托单位: SCHWARTZ ELECTRO-OPTICS, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-05 至 1992-12-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3492881
• 关键词: bioengineering /biomedical engineering; bladder neoplasm; carcinoma; clinical biomedical equipment; cytotoxicity; laser therapy; neoplasm /cancer photoradiation therapy; neoplastic cell; photosensitizing agents; phthalocyanin; porphyrins; tissue /cell culture

DESCRIPTION (Adapted from applicant's abstract):Photodynamic therapy (PDT) utilizing hematoporphyrin derivative (HPD) and a cw argon-pumped dye laser tuned to 630 nm has been shown to be a promising treatment for a number of forms of cancer. However, because tissue penetration is maximized for wavelengths greater than 700 nm, substantial effort has been directed towards finding new dyes which absorb in the near-ir (670-900 nm). The tuning range of the recently developed Ti:sapphire laser overlaps this regions, thus providing an all-solid-state alternative to the dye laser. The Phase I effort will involve cell-level experiments using two new photosensitizers: sulfonated chloraluminum phthalocyanine (CASPc) and benzoporphryin derivative monoacid A (BPD) which absorb at 680 nm and 690 nm respectively. Although a Ti:sapphire system can be operated either pulsed or cw in this wavelength region, the initial experiments will be performed with a pulsed laser, since the cw Ti:sapphire would produce results that were very similar to the cw dye. Although the primary cause of cell necrosis under cw irradiation is the creation of singlet oxygen, the high intensity levels generated by the pulsed laser may photosensitize by non-oxygen-dependent mechanisms. The long term goal would be to develop a clinically qualified solid-state laser for PDT.

描述（改编自申请人摘要）：光动力疗法（PDT） 利用血卟啉衍生物（HPD）和连续波氩泵浦染料激光器， 调谐到630 nm已被证明是一个有前途的治疗许多 癌症的形式。 然而，由于组织渗透最大化， 波长大于700 nm，已经进行了大量努力 致力于寻找在近红外（670-900 nm）吸收的新染料。 的 最近开发的钛宝石激光器的调谐范围与此重叠 区，从而提供了一个全固态的染料激光器的替代品。 第一阶段的工作将涉及细胞水平的实验，使用两种新的 光敏剂：磺化氯铝酞菁（CASPc）和 苯并卟啉衍生物单酸A（BPD）在680 nm和690 nm处有吸收 nm分别。 虽然钛：蓝宝石系统可以操作， 脉冲或CW在这个波长范围内，最初的实验将是 用脉冲激光进行，因为连续Ti：蓝宝石将产生 结果与CW染料非常相似。 虽然主要原因 CW辐射下细胞坏死的主要原因是单线态氧的产生， 由脉冲激光产生的高强度水平可以光敏化 通过非氧依赖机制。 长期目标是发展 临床合格的PDT固态激光器。