HOLMIUM LASER FOR REVERSAL OF CEREBRAL ARTERY VASOSPASM
钬激光逆转脑动脉血管痉挛
基本信息
- 批准号:2029412
- 负责人:
- 金额:$ 40.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1995
- 资助国家:美国
- 起止时间:1995-06-01 至 1999-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Cerebral artery vasospasm is a life-threatening condition triggered
by bleeding aneurysms that can cause severe neurological damage.
The number of patients suffering from cerebral vasospasm is in
excess of 20,000, and the condition often produces permanently
crippling effects or death in the 30-40 year old age group that
exhibits the highest incidence. The condition responds poorly to
drugs and is difficult to treat with balloon angioplasty. On Phase
I, we developed a pulsed-holmium-laser-driven catheter which
emitted fluid waves that reliably and permanently relieved
hemorrhage-induced spasm in canine brain arteries. During Phase ll,
we will first verify the exact procedure and hardware to be used in
patients, then conduct the first clinical trial of this approach in
patients with papaverine-resistant cerebral artery vasospasm. A
life-saving treatment for vasospasm will result directly from this
work.
PROPOSED COMMERCIAL APPLICATIONS At present, there is no permanent
treatment for severe cerebral artery vasospasm. Approximately
10,000 healthy, young adults suffer permanent brain damage due to
cerebral vasospasm each year, and the development of a permanent
laser-based treatment would significantly reduce the number of
patients disabled by this condition.
脑动脉血管痉挛是一种危及生命的疾病,
动脉瘤出血会导致严重的神经损伤
患上脑血管痉挛的病人人数,
超过20,000,并且这种情况经常产生永久性的
在30-40岁年龄组中,
发病率最高。这种情况对
药物,并且难以用球囊血管成形术治疗。相
我,我们开发了一种脉冲钬激光驱动的导管,
发出的流体波可靠而持久地缓解了
犬脑动脉的血管痉挛。在第二阶段,
我们将首先验证要使用的确切程序和硬件,
患者,然后进行这种方法的第一次临床试验,
罂粟碱抵抗性脑动脉血管痉挛患者。一
血管痉挛的救生治疗将直接由此产生
工作
建议的商业应用目前,
治疗严重的脑动脉血管痉挛。 约
10,000名健康的年轻成年人因以下原因而遭受永久性脑损伤:
脑血管痉挛每年,并发展为永久性
基于激光的治疗将大大减少
患者因这种情况而致残。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PETER F MOULTON其他文献
PETER F MOULTON的其他文献
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{{ truncateString('PETER F MOULTON', 18)}}的其他基金
HOLMIUM LASER FOR REVERSAL OF CEREBRAL ARTERY VASOSPASM
钬激光逆转脑动脉血管痉挛
- 批准号:
2771421 - 财政年份:1995
- 资助金额:
$ 40.78万 - 项目类别:
HOLMIUM LASER FOR REVERSAL OF CEREBRAL ARTERY VASOSPASM
钬激光逆转脑动脉血管痉挛
- 批准号:
2232757 - 财政年份:1995
- 资助金额:
$ 40.78万 - 项目类别:
PULSED SOLID-STATE LASER SOURCE FOR PHOTODYNAMIC THERAPY
用于光动力治疗的脉冲固态激光源
- 批准号:
3492881 - 财政年份:1992
- 资助金额:
$ 40.78万 - 项目类别:
SOLID STATE LASER FOR VASCULAR LESION TREATMENT
用于血管病变治疗的固态激光器
- 批准号:
3502224 - 财政年份:1992
- 资助金额:
$ 40.78万 - 项目类别:
TUNABLE-WAVELENGTH SCANNING LASER OPHTHALMOSCOPE
可调谐波长扫描激光检眼镜
- 批准号:
2162483 - 财政年份:1991
- 资助金额:
$ 40.78万 - 项目类别:
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