SOLID-STATE LASER SOURCE FOR CORNEAL ABLATION

用于角膜切削的固态激光源

• 批准号: 3497148
• 负责人: PETER F MOULTON
• 金额: $ 5万
• 依托单位: SCHWARTZ ELECTRO-OPTICS, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-01 至 1992-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3497148
• 关键词: animal tissue; biomedical equipment development; clinical biomedical equipment; cornea; eye laser surgery; gas poisoning; heat injury; human tissue; infrared radiation; lasers; refractive keratoplasty; ultraviolet radiation

DESCRIPTION (Adapted from applicant's abstract): Corneal sculpting is a new technique that uses an ultraviolet laser to correct refractive vision disorders by ablating a portion of the cornea. Current clinical systems use the ArF excimer laser operating at 193 nm, which produces sharply defined corneal incisions with minimal damage to adjacent tissue. The development of a solid-state alternative to the excimer is now possible due to advances in the growth of non-linear crystals with favorable UV properties. By using a tunable pulsed Ti:Sapphire laser as the pump source, a wide range of UV wavelengths can be generated via non-linear frequency conversion. As part of the Phase I effort, the near-IR output of a pulsed Ti:Sapphire laser will be converted to the 205-225 nm region via frequency quadrupling in two beta-barium borate crystals. The objective of this work is to determine whether the quality of the corneal incisions made using wavelengths ranging from 205-225 nm compare favorably with those made by the 193 nm excimer. If a wavelength within this range does prove to be useful for corneal ablation, the long term goal of this program would be to develop a clinically qualified solid-state laser for refractive surgery.

描述（改编自申请人摘要）：角膜雕刻是一种 一种使用紫外线激光矫正屈光视力的新技术 通过切除一部分角膜来治疗疾病。 当前临床系统 使用ArF准分子激光器在193 nm处工作， 定义角膜切口，对邻近组织的损伤最小。 的 现在有可能开发出一种固态的准分子替代品， 在生长非线性晶体方面取得了进展， 特性. 采用可调谐脉冲钛宝石激光器作为泵浦源， 源，可以通过非线性产生宽范围的UV波长 变频 作为第一阶段工作的一部分， 激光将通过四倍频转换到205-225 nm区域 在两个β-硼酸钡晶体中。 这项工作的目标是 确定是否使用角膜切口的质量 波长范围为205-225 nm的光与通过以下方法制备的光相比是有利的： 193 nm准分子。 如果在这个范围内的波长确实被证明是 对于角膜消融有用，该计划的长期目标是 开发临床合格的用于屈光手术的固态激光器。