用于紫杉醇定向递送的双特异性抗体-猫眼课题宝

用于紫杉醇定向递送的双特异性抗体

批准号：

3493114

负责人：

Gary Steven Bignami

金额：

$5.0万

依托单位：

HAWAII BIOTECH, INC.

依托单位国家：

美国

项目类别：

财政年份：

1992

资助国家：

美国

项目状态：

已结题

起止时间：

1992-03-11 至 1992-10-31

来源：

https://reporter.nih.gov/project-details/3493114

关键词：

antineoplastics antitumor antibody chromatography clone cells drug delivery systems drug design /synthesis /production gel electrophoresis hybrid antibody hybridomas immunoconjugates immunologic assay /test immunotoxicity laboratory mouse neoplastic cell paclitaxel protein purification thioether

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DESCRIPTION: (Adapted from the Applicant's Abstract). It is proposed to achieve the selective delivery of cytotoxic agents through the use of bispecific antibodies. Taxol is a promising new anticancer agent isolated in low yield from the bark of the Pacific yew tree, Taxus brevifolia. The applicant will prepare a thioether-linked bispecific antibody with dual specificity for taxol and human cancer cells. It is asserted that this bispecific antibody will potentiate the action of taxol in target tissue, minimize side-effects, and reduce the total amount of taxol required for effective therapy.

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