BRAIN IMAGING QUANTITIATION TECHNIQUES

脑成像定量技术

• 批准号: 3504279
• 负责人: HARRY L LOATS
• 金额: $ 4.97万
• 依托单位: LOATS ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1989-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3504279
• 关键词: biomedical equipment development; computed axial tomography; image enhancement; image processing; magnetic resonance imaging

The goal of this Phase I effort is to develop and validate a capability for quantitative analysis and display of CT, MRI, and ECT images of the brain. We propose to develop and validate the overall approach of multi-model image registration and display of the images, filtering of ECT data to simultaneously enhance resolution and reduce noise, and techniques to generate precise quantitation of two and three-dimensional regions of interest. There are six major project elements. Registration will be accomplished using external fiducials. Rescaling will use anamorphically stretching of the film images. Filtering will use advanced Fourier analysis. Quantitation will include six distinct models of spatial ROI sampling. 3D display/quantitation will be developed with interactive capabilities based on existing 3D display techniques. Automated Regions of Interest will allow the user three modalities to select specific areas. Statistical treatment of the data will be built into the program. The vehicle for these capabilities will be a version of the Loats associates Biomedical Image analysis System which was developed n part with the support of an SBIR Grant.

第一阶段工作的目标是开发和验证 能够定量分析和显示CT、MRI和 脑的ECT图像 我们建议制定和验证 多模型图像配准与显示的整体方法 图像，过滤ECT数据，同时增强 分辨率和减少噪音，以及技术，以产生精确的 二维和三维感兴趣区域的定量。 项目有六大要素。 报名将 使用外部基准完成。 重新缩放将使用 变形拉伸的电影图像。 过滤将使用 高级傅立叶分析 定量将包括六种不同的 空间ROI采样模型。 3D显示/定量将是 基于现有的3D技术， 显示技术 自动感兴趣区域将允许 用户可以选择三种模式的特定区域。 统计 数据的处理将被纳入程序。 车辆 这些能力将是一个版本的Loats联营公司 生物医学图像分析系统，该系统是与 获得SBIR赠款的支持。

项目成果

CT and SPECT image registration and fusion for spatial localization of metastatic processes using radiolabeled monoclonals.

使用放射性标记的单克隆抗体进行 CT 和 SPECT 图像配准和融合，用于转移过程的空间定位。

• 发表时间: 1993
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Loats,H