LOW-COST, RED LIGHT SOURCE FOR PHOTODYNAMIC THERAPY

用于光动力治疗的低成本红光源

• 批准号: 3493288
• 负责人: KARLHEINZ STROBL
• 金额: $ 4.98万
• 依托单位: COGENT LIGHT TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1993-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3493288
• 关键词: athymic mouse; basal cell carcinoma; biomedical equipment development; charge coupled device camera; clinical biomedical equipment; disease /disorder model; fiber optics; neoplasm /cancer photoradiation therapy; nonhuman therapy evaluation; photosensitizing agents; skin neoplasms; visible light

Photodynamic Therapy (PDT) has been hypothesized to be a new method for treatment of skin tumors like recurring basal cell carcinomas and has been demonstrated in clinical trial to be an alternative for controlling malignancies such as bladder, esophagus and lung cancers. The method depends on the selective retention of a photosensitizer by the tumor and its subsequent in situ activation by light of appropriate e wavelength and tissue penetration. The primary objective of this research proposal is to build and test a novel, low cost, non-laser, fiber optic red light source that has the potential to provide equivalent PDT bio-effects, but at much lower installation, maintenance and hardware cost and with greater safety compared to lasers. The goals of phase I are (1) to build and characterize a prototype, red light source with a fiber optic hand piece to illuminate uniformly skin areas (up to 1.5 cm in diameter) with 150 mW/cm2 of red light (630 plus/minus 15 nm) and (2) to test and quantify in an appropriate animal model its effectiveness for PDT in connection with the photosensitizing drug Photofin II. In phase II engineering prototypes would be developed and tested in a series of limited clinical studies.

光动力疗法(PDT)被认为是一种新的治疗方法 皮肤肿瘤的治疗，如复发性基底细胞癌和 已在临床试验中证明是一种控制 恶性肿瘤，如膀胱癌、食道癌和肺癌。方法 取决于肿瘤对光敏剂的选择性保留和 随后用适当e波长的光进行原位激活 和组织穿透。这项研究提案的主要目的是 是建造和测试一种新型的、低成本的、非激光的光纤红灯 有可能提供等同的PDT生物效应的来源，但 更低的安装、维护和硬件成本， 比激光更安全。第一阶段的目标是(1)建立 并描述了一个原型，一个带有光纤手的红色光源 用来均匀地照亮皮肤区域(直径最大1.5厘米) 150 mW/cm2红光(630正/负15 nm)和(2)以测试和 在适当的动物模型中量化其对光动力疗法的有效性 与光敏药物Photofin的关系II.在II期 工程原型将在一系列 有限的临床研究。