TIME INTEGRATED MEASUREMENT OF HORMONE AVAILABILITY

激素可用性的时间综合测量

• 批准号: 3508973
• 负责人: STEPHEN E WADE
• 金额: $ 27.82万
• 依托单位: HAMMERSMITH LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508973
• 关键词: biosensor device; clinical biomedical equipment; clinical depression; corticosterone; cortisol; high performance liquid chromatography; human subject; implant; laboratory rat; monitoring device; pharmacokinetics; saliva

The proposed research will test the utility in clinical psychiatric applications of a newly- developed method for measurement of the hormone cortisol. The new method uses an ultraminiature device, installed in the mouth of a subject, to continuously accumulate cortisol from the saliva. The rate of accumulation at any moment directly reflects the availability of this hormone to tissue. The total accumulation over some time (1 to 10 h) reflects the time integral of cortisol availability to tissue. This is advantageous since cortisol levels in the circulation and in the saliva fluctuate widely over short time intervals, and less than 10% of cortisol in blood is actually available to tissue. The new method represents both the most direct and the least invasive way of determining the actual degree of tissue exposure to cortisol. Brain hyperexposure to cortisol is implicated in the etiology of some forms of depression, and is thought to accompany sleep disorders, cognitive deficits, and psychotic features of depression. Further, abnormalities of cortisol regulation occur in a state-dependent way in depression, so that monitoring cortisol regulation regularly may allow prediction of the clinical course of the disease. If the new method proves to have diagnostic or predictive utility in psychiatry, widespread clinical use and commercial success are expected.

这项拟议的研究将测试其在临床精神病学中的效用。 一种新开发的测量方法的应用 荷尔蒙皮质醇。新方法使用了一种超微型设备， 安装在受试者的嘴里，不断积累 唾液中的皮质醇。任何时刻的累积速度 直接反映了这种荷尔蒙对组织的可用性。这个 一段时间(1到10小时)的累计反映了时间 皮质醇对组织可利用性的积分。这是有利的 因为血液循环和唾液中的皮质醇水平 在短时间间隔内波动很大，不到10% 血液中的皮质醇实际上可以被组织利用。新方法 代表了最直接和最不具侵入性的方式 确定组织暴露于皮质醇的实际程度。 大脑对皮质醇的过度暴露与高血压的病因学有关 某些形式的抑郁症，被认为伴随着睡眠 精神障碍、认知缺陷和精神病特征 抑郁症。此外，皮质醇调节也会出现异常。 在抑郁症中以一种状态依赖的方式，因此监测皮质醇 有规律的管理可以预测临床病程。 这种疾病的危害。如果新方法被证明具有诊断性或 在精神病学中的预测效用，广泛的临床应用和 商业上的成功是可以预期的。