FISH VENTILATORY BEHAVIOR AS A TOXIC'S MONITORING TOOL

鱼类的呼吸行为作为有毒物质的监测工具

• 批准号: 3496463
• 负责人: DAVID GRUBER
• 金额: $ 5万
• 依托单位: BIOLOGICAL MONITORING, INC.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-15 至 1986-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3496463
• 关键词: aquatic biology; artificial intelligence; bioassay; chemical structure function; chlorohydrocarbon; cinematography; computer graphics /printing; environmental contamination; environmental toxicology; fresh water environment; gills; metal poisoning; monitoring device; pesticide biological effect; toxicant screening; trichloroethylene; water pollution; water pollution control; water sampling /testing; water supply; zinc

The long term objective is to develop a fish monitoring tool capable of rapidly screening chemicals for toxicity, protecting public drinking water supplies and wastewater receiving systems, and identifying the causative toxic agent(s). Non-invasive electrode techniques receive signals from fish generated bioelectric fields. Electronic components filter the signals generated from independently monitored fish such that the ventilatory components may be amplified and interfaced to a microcomputer. This and other laboratories have demonstrated that, upon exposure to acutely toxic chemical concentrations, several changes occur in the ventilatory components of fish, such as, frequency, amplitude, and gill purge or cough, including three major and eleven subcategories of the types of gill purge. It is anticipated that the Phase I research will demonstrate that, upon exposure to chronically toxic chemical concentrations, the combinations of ventilatory components occurring will be unique to a given category of the chemical (e.g., concepts of structural activity relationships, heavy metal vs. pesticide, etc.). Many chemicals that are toxic to humans and other mammilian systems are toxic to aquatic organisms. If the long term objective is successful, this inexpensive monitoring tool would have commercal applications for the chemical manufacturing, drinking water and wastewater treatment industries, municipalities, and regulatory agencies, as well as the academic research community.

长期目标是开发能够 快速筛查毒性化学物质，保护公共饮用水 供应和废水接收系统，并确定因果关系 有毒药物。 非侵入性电极技术接收信号 鱼产生的生物电场。 电子组件过滤 由独立监测的鱼产生的信号，使得 通气组件可以扩增并连接到微型计算机。 这个和其他实验室已经证明，暴露于 急性毒性化学浓度，发生了几种变化 鱼类的通气成分，例如，频率，振幅和g 清除或咳嗽，包括类型的三个主要和11个子类别 吉尔清除。 预计我的研究将 证明，暴露于慢性毒性化学物质后 浓度，发生的通气组件的组合将 在给定类别的化学类别中是独特的（例如，结构的概念 活动关系，重金属与农药等）。 许多化学物质 对人类和其他哺乳动物系统有毒的对水生有毒 有机体。 如果长期目标是成功的，那么这个便宜 监视工具将对化学物质有商业应用 制造，饮用水和废水处理行业， 市政当局和监管机构以及学术研究 社区。