Cloning and characterisation of a bipolar disorder susceptibility gene on chromosome 15q

15q 染色体双相情感障碍易感基因的克隆和表征

• 批准号: nhmrc : 510216
• 负责人: A/Pr Jennifer Donald
• 金额: $ 23.18万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cloning-characterisation-bipolar-chromosome-15q/76396
• 关键词: Cloning; characterisation; bipolar; disorder; susceptibility

Bipolar disorder is a severe mood disorder, characterised by aberrant mood swings resulting in periods of mania and depression. We need to define more clearly the biological basis of bipolar disorder to improve diagnosis and treatment. Bipolar disorder is highly heritabile allowing the use of genetics to identify the predisposing genes. Our aim is to identify a bipolar susceptibility gene on chromosome 15 and to understand how this gene contributes to the risk of developing bipolar disorder.

双相情感障碍是一种严重的情绪障碍，其特征是异常的情绪波动，导致躁狂和抑郁的时期。我们需要更清楚地定义双相情感障碍的生物学基础，以改善诊断和治疗。双相情感障碍是高度遗传性的，允许使用遗传学来识别易感基因。我们的目的是确定15号染色体上的双相情感易感基因，并了解该基因如何导致双相情感障碍的风险。