INTEGRATED COLUMN/MULTISENSOR MICROBORE SYSTEM

Fritt型库仑传感器的基本特性使它们 独一无二的适用于高灵敏电化学液相色谱 微孔系统中的检测专门设计以优化其 属性。建议的工作是基于优化一个概念上简单的 多传感器阵列中的第一个传感器是 保持微孔柱的熔块。初步研究表明 将概念发展为集成系统泵的可取性， 柱、传感器、检测器-将带宽扩展和噪声降至最低。特定的 儿茶酚胺10 FG灵敏度的主要设计目标 代谢物已根据可行性和要求建立 建议在微透析和 显微组织分析。通过以下方式优化分辨率的辅助设计目标 还提出了利用多个串联传感器进行测量的方法。该提案是 旨在开发一系列模块化设备，用于 将市场作为完整的独立包或改装来进行研究 现有的泵和探测器。

The basic characteristics of fritt type coulometric sensors make them uniquely suited for high sensitivity liquid chromatography electrochemical detection in microbore systems specifically engineered to optimize their properties. The proposed work is based on optimizing a conceptually simple design in which the first sensor in a multiple sensor array is the retaining fritt of a microbore column. Preliminary studies have indicated the desirability of developing the concept as an integrated system - pump, column, sensor, detector - to minimize bandspreading and noise. Specific primary design goals of 10 fg sensitivity for catecholamines and metabolites have been established based on feasibility and the requirements of the specific applications studies proposed in microdialysis and microtissue assays. secondary design goals of optimizing resolution by utilizing multiple series sensors ar-e also proposed. The proposal is directed towards the development of a modular series of devices for the research market as either complete stand alone packages or retrofits to existing pumps and detectors.