MODULAR EXPERT SYSTEM FOR HPLC METHOD DEVELOPMENT

用于 HPLC 方法开发的模块化专家系统

• 批准号: 3498561
• 负责人: LLOYD R SNYDER
• 金额: $ 4.97万
• 依托单位: LC RESOURCES, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3498561
• 关键词: artificial intelligence; biomedical equipment development; computer program /software; computer simulation; high performance liquid chromatography

Despite 10 years of intensive research into computer-assisted method development for HPLC separation, relatively few chromatographers use these techniques to a significant extent. We propose to develop a computer program (MOSES - Modular Optimization Software/Expert System) that addresses this problem. Computer-simulation modules based on chromatographic theory will be integrated into an expert system framework that addresses most of the problems encountered during HPLC method development. The program will be applicable to both small-molecule samples (which most previous work addresses) and to large biomolecules of interest in the life sciences. The program will also assist in the selection of initial conditions, sample pretreatment, optimizing the separation and scaling up for preparative separation. Previously recognized needs in computer-assisted method development (e.g., user-friendly environment, reliable and convenient mapping of separation, peak tracking, etc.) will be addressed.

尽管对计算机辅助方法进行了10年的深入研究， 由于HPLC分离的发展，相对较少的色谱仪使用这些 技术在很大程度上。我们建议开发一种计算机 程序（MOSES -模块化优化软件/专家系统） 解决了这个问题。计算机模拟模块基于 色谱理论将被集成到一个专家系统框架中 解决了HPLC方法中遇到的大部分问题 发展该程序将适用于两种小分子样品 （大多数以前的工作地址）和感兴趣的大生物分子 在生命科学中。该计划还将协助选择 初始条件、样品预处理、分离条件优化、 按比例放大用于制备分离。以前确认的需求 计算机辅助方法开发（例如，用户友好的环境， 分离、峰跟踪等的可靠和方便的映射）将 处理。