MODULAR EXPERT SYSTEM FOR HPLC METHOD DEVELOPMENT

用于 HPLC 方法开发的模块化专家系统

• 批准号: 3508022
• 负责人: LLOYD R SNYDER
• 金额: $ 23.73万
• 依托单位: LC RESOURCES, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508022
• 关键词: artificial intelligence; biomedical automation; computer assisted instruction; computer simulation; computer system design /evaluation; high performance liquid chromatography; information systems; macromolecule; method development

The goal of this program is the development of a computer program (MOS/ES: modular optimization software/expert system) for the facilitation of HPLC method development. Phase I achieved the following objectives: (1) prototype expert system software that allows the development of an isocratic HPLC method, (2) a new computer-simulation module that can be used for the isocratic optimization of any separation variable (e.g., pH, ternary-solvent compositions, etc.), (3) an initial version of peak tracking software and (4) computer simulation software for the separation of large biomolecules. Phase II proposes to accomplish several tasks: (1) completion of the expert system begun in Phase I, (2) development of software based on a new approach to HPLC method development (restricted multi-parameter optimization), (3) automation of the selection of certain experimental conditions, (4) development of an interface that allows the MOS/ES program to control the HPLC hardware and (5) extension of the present approach (MOS/ES) to include preparative separations.

该计划的目标是开发计算机程序（MOS/ES： 模块化优化软件/专家系统）以促进 HPLC 方法开发。 第一阶段实现了以下目标：（1） 原型专家系统软件，允许开发 等度 HPLC 方法，(2) 一种新的计算机模拟模块，可以 用于任何分离变量（例如 pH、 三元溶剂组合物等），（3）峰的初始版本 跟踪软件和（4）分离计算机模拟软件 大生物分子。 第二阶段拟完成几项任务：（1）完成 专家系统第一阶段开始，（2）基于新的软件开发 HPLC 方法开发方法（限制性多参数 优化），（3）某些实验选择的自动化 条件，（4）开发允许MOS/ES程序的接口 控制 HPLC 硬件和 (5) 本方法的扩展 (MOS/ES) 包括制备分离。