NOVEL SOFT X-RAY IMAGING MICROSCOPE DIFFRACTION PLATE
NOVEL SOFT X-RAY IMAGING MICROSCOPE DIFFRACTION PLATE
批准号:
3498596
负责人:
JOSEPH BLANC
金额:
$5.0万
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-09-01 至 1992-03-31
中文摘要
X射线光学中的一个新想法可以通过成像软件来改善通量。
X射线显微镜被放大了一个数量级。如此重大的进步
在开发小规模的商业x-
与现有设备一起在实验室中使用的射线显微镜。
该装置是一种软X射线衍射板,也将消除昂贵的,
难以制造聚光器光学元件并减少对准限制。
将建立衍射板的详细数学模型
使用分析和计算机技术。这些将被用来决定
哪种制作方法会产生最好的衍射光
通过将所获得的数据与18.2 nm激光在
普林斯顿大学等离子体物理实验室的理论。
在这些测试的基础上,软x射线成像显微镜将被
设计包含衍射板,可在
第二阶段。这种仪器将使有希望的成像工作成为可能
50纳米分辨率的水合生物标本目前正在
同步加速器将转移到大学实验室环境中-
它是否有望产生对微观结构的重大洞察
水合的,没有染色的细胞。
英文摘要
A new idea in x-ray optics could improve the flux through an imaging soft
x-ray microscope by an order of magnitude. Such a significant improvement
would be particularly important in developing a small scale, Commercial x-
ray microscope for use in laboratories alongside existing equipment.
The device, a soft x-ray diffraction plate, would also eliminate costly,
difficult to fabricate condenser optics and reduce alignment constraints.
Detailed mathematical models of the diffraction plate will be developed
using analytical and computer techniques. These will be used to decide
which of several methods of manufacture will produce the best diffraction
plates by comparing the data obtained with the 18.2 nm lasers at
Princeton's Plasma Physical Laboratory with theory.
On the basis of these tests, a soft x-ray imaging microscope will be
designed incorporating a diffraction plate, ready for construction in
Phase II. Such an instrument would enable promising work on imaging
hydrated biological specimens at 50 nm resolution currently being done at
synchrotrons to be transferred to the university laboratory environment -
were it is expected to yield significant insights into the microstructure
of hydrated, unstained cells.
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ATTRACTIVE ATOMIC FORCE MICROSCOPY FOR DNA SEQUENCING
-
批准号:3505304
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1991
-
负责人:JOSEPH BLANC
-
依托单位:
READ-OUT INSTRUMENTATION FOR X-RAY CONTACT MICROSCOPY
-
批准号:3498280
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1990
-
负责人:JOSEPH BLANC
-
依托单位:
海外基金