X-ray elastography: a novel approach to breast imaging

X 射线弹性成像：一种新的乳腺成像方法

• 批准号: EP/P005209/1
• 负责人: Peter Munro
• 金额: $ 12.82万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP005209%2F1
• 关键词: ray; elastography; novel; approach; breast

The mechanical properties of tissue, such as stiffness, have long been known to be an important indicator of the health of tissue. Indeed, manual palpation is used regularly by clinicians as part of routine diagnostic procedures. A range of techniques have been developed in order to obtain images, both in two and three dimensions, of tissue stiffness. This approach, known as elastography, is significantly more powerful than manual palpation as the clinician is able to visualise the location, and relative stiffness, of tissue within the body.Existing elastography techniques are based on ultrasonoghraphic imaging (i.e. ultrasound, US), magnetic resonance imaging (MRI) and optical imaging. US based elastography has developed to the point where it is able to be used as part of a routine breast cancer diagnosis protocols. One of the problems with these established techniques is that their ability to resolve small features, such as small tumours, degrades as these tumours are located within the body. For example, optical techniques are able to resolve features as small as 0.02mm, however, only if they are located within about 1mm of the skin. Tumours over 0.1mm in size can be detected using US elastography if they are located less than 10cm from the skin surface, and so on.We propose to make use of a recently developed X-ray imaging technique, known as phase imaging, which provides images of biological tissue which are much clearer than conventional X-ray imaging. Using this technique we believe it will be possible to obtain images of tissue stiffness, resolving features as small as 0.02mm, located deep within the body, thus breaking the limitation of existing elastography techniques. Although applicable to a range of applications, we will apply this technique to breast cancer imaging. If successful, the technique could be applied in screening, diagnosis and treatment of breast cancer. In particular, it could be integrated into a form of three-dimensional mammography known as tomosynthesis, giving the radiologist an additional form of contrast upon which to make their diagnosis. Once a suspicious lesion has been detected at the screening stage, this technique could be used in follow up imaging, again to provide the radiologist with an additional form of contrast upon which to make their diagnosis. Finally, if surgery is required, it may be possible to use this technique to check that the tumour has been completely removed at the time of surgery, rather than requiring a patient to return for follow-up surgery to remove any remaining tumour.

组织的机械性能，例如刚度，长期以来一直被认为是组织健康的重要指标。事实上，临床医生经常使用手动触诊作为常规诊断程序的一部分。为了获得组织硬度的二维和三维图像，已经开发了一系列技术。这种方法被称为弹性成像，比手动触诊更强大，因为临床医生能够可视化体内组织的位置和相对硬度。现有的弹性成像技术基于超声成像（即超声，US）、磁共振成像（MRI）和光学成像。美国的弹性成像技术已经发展到能够用作常规乳腺癌诊断方案的一部分。这些现有技术的问题之一是，当这些肿瘤位于体内时，它们解决小特征（例如小肿瘤）的能力就会降低。例如，光学技术能够解析小至 0.02 毫米的特征，但前提是它们位于距离皮肤约 1 毫米以内。如果肿瘤距离皮肤表面小于 10 厘米，则可以使用超声弹性成像来检测大小超过 0.1 毫米的肿瘤等。我们建议利用最近开发的 X 射线成像技术，称为相位成像，它提供比传统 X 射线成像更清晰的生物组织图像。我们相信使用这项技术将有可能获得组织硬度的图像，解析位于身体深处小至 0.02 毫米的特征，从而打破现有弹性成像技术的限制。尽管适用于一系列应用，但我们将将该技术应用于乳腺癌成像。如果成功，该技术可应用于乳腺癌的筛查、诊断和治疗。特别是，它可以集成到一种称为断层合成的三维乳房X线照相术中，为放射科医生提供一种额外的对比形式来进行诊断。一旦在筛查阶段检测到可疑病变，该技术就可以用于后续成像，再次为放射科医生提供一种额外的对比形式来进行诊断。最后，如果需要手术，可以使用这种技术在手术时检查肿瘤是否已完全切除，而不是要求患者返回进行后续手术以切除任何剩余的肿瘤。

项目成果

Development of a reliable and reproducible phantom manufacturing method using silica microspheres in silicone.

使用硅树脂中的二氧化硅微球开发可靠且可重复的模型制造方法。

• DOI: 10.1117/1.jbo.22.9.095004
• 发表时间: 2017
• 期刊: Journal of biomedical optics
• 影响因子: 3.5
• 作者: Maughan Jones C

Volumetric quantitative optical coherence elastography with an iterative inversion method.

采用迭代反演方法的体积定量光学相干弹性成像。

• DOI: 10.1364/boe.10.000384
• 发表时间: 2019
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Dong L

Stability of gel wax based optical scattering phantoms.

• DOI: 10.1364/boe.9.003495
• 发表时间: 2018-08-01
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Jones CJM;Munro PRT
• 通讯作者: Munro PRT