SENSITIVE PROBE FOR INTRA-OPERATIVE BONE SCANNING

用于术中骨扫描的灵敏探头

• 批准号: 3506256
• 负责人: GERALD ENTINE
• 金额: $ 13.35万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3506256
• 关键词: bone imaging /visualization /scanning; bone neoplasms; clinical biomedical equipment; diagnostic tests; hip surgery; neoplasm /cancer surgery; nuclear medicine; radiation detector; radionuclide diagnosis; radionuclide imaging /scanning; surgery

Advances in nuclear medical scanning techniques including the use of radiotracers employing antibodies, liposomes and other biochemical targeting agents are now becoming widely accepted as extremely effective approaches to imaging. However, their utility in the operating room during surgery has been severely limited by the absence of a convenient and sensitive hand held nuclear probe to assist in delineating the boundries of the design. Our research has clearly shown the feasibility of using a cadmium telluride solid state radiation detector as the basis of an extremely sensitive, miniaturized instrument for intra-operative tumor localization. The research program will address both the semiconductor detector and electronic aspects of the probe. In collaboration with the Queen's Hospital in England, the Wilshire Oncology Group in St. Vincent's Hospital, and the University of Rochester Medical Center, a fully self contained, all solid state nuclear surgical probe will have been developed which will be suitable for use with a very wide variety of tumor seeking agents.

核医学扫描技术的进展，包括使用 采用抗体、脂质体和其他生化物质的放射性示踪剂 靶向剂现在被广泛接受为极其有效的 接近成像。 然而，它们在手术室中的效用， 由于缺乏一种方便的， 灵敏的手持核探测器，以协助划定边界的 设计。 我们的研究已经清楚地表明了使用碲化镉的可行性 固态辐射探测器作为一个极其敏感的基础， 用于术中肿瘤定位的小型化仪器。 该研究计划将同时解决半导体探测器和 探头的电子方面。 与女王的合作 英格兰的医院，圣文森特医院的威尔希尔肿瘤小组， 和罗切斯特大学医学中心，一个完全独立的，所有 固态核手术探针将被开发出来，这将是 适合与多种肿瘤导向剂一起使用。