HIGH RESOLUTION NUCLEAR CARDIAC IMAGING

高分辨率核心脏成像

• 批准号: 7270088
• 负责人: GERALD ENTINE
• 金额: $ 42.67万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7270088
• 关键词: 3-Dimensional; Address; Anodes; Area; Benchmarking; Brain; Bromides; Caliber; California; Cardiac; Caring; Cerium; Cherry - dietary; Collaborations; Collection; Collimator; Coronary Arteriosclerosis; Count; Coupled; Coupling; DCNU; Depth; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Elements; Emission-Computed Tomography; Evaluation; Feasibility Studies; Floods; Gamma Rays; Generations; Goals; Growth; Image; Imaging Techniques; Invasive; Investigation; Isotopes; Kidney; Laboratories; Lanthanum; Length; Light; Liver; Localized; Logic; Lung; Malignant Neoplasms; Measures; Medical Imaging; Metabolism; Methods; Modality; Myocardial; Myocardial perfusion; Nuclear; Numbers; Optics; Organ; Output; Patients; Penetration; Pennsylvania; Performance; Personal Satisfaction; Phase; Photons; Play; Positron; Positron-Emission Tomography; Process; Property; Prostate; Published Comment; Radial; Radioisotopes; Rate; Reporting; Research; Resolution; Role; Saints; San Francisco; Semiconductors; Silicon; Skeletal system; Slice; Source; Speed; Symptoms; System; Techniques; Technology; Temperature; Thick; Three-Dimensional Imaging; Time; Tube; Universities; Visual; X-Ray Computed Tomography; attenuation; base; clinical Diagnosis; cost; density; design; desire; detector; improved; instrumentation; light emission; melting; outcome forecast; photomultiplier; prototype; response; scale up; simulation; single photon emission computed tomography; size; thallium-doped sodium iodide; tool

DESCRIPTION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an image of the three dimensional distribution of a radionuclide in any slice through an organ under study in the body. These images allow investigation of metabolism in the region being studied and are a useful tool for understanding the functioning of the organs as well as diagnosing symptoms of diseases. Nuclear medicine is a very important modality in cardiac imaging, providing both diagnosis as well as prognosis. SPECT is more commonly used in localizing coronary artery disease and as many as 90% of myocardial perfusion studies are now performed using SPECT. The role of PET in cardiac imaging is gradually expanding, particularly in the areas of detecting coronary artery disease (where it shows ~10 to 15% higher accuracy then SPECT) and assessing myocardial viability. Recent developments in combining nuclear medicine with X-ray CT imaging provide better attenuation correction in cardiac imaging studies. It is clear that nuclear medicine technologies are playing a prominent and an increasingly important role in cardiac care and clinical diagnosis. However, there is urgent need for improvement in the performance of these imaging modalities in order to exploit their full potential. The goal of the proposed effort is to investigate a new high resolution detector for nuclear medicine.

描述（由申请人提供）：诸如单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）之类的核医学成像模式是强大的非侵入性医学成像技术，其提供通过体内研究器官的任何切片中的放射性核素的三维分布的图像。这些图像允许研究正在研究的区域的代谢，并且是理解器官功能以及诊断疾病症状的有用工具。核医学是心脏成像中非常重要的方式，提供诊断以及预后。SPECT更常用于冠状动脉疾病的定位，现在多达90%的心肌灌注研究使用SPECT进行。PET在心脏成像中的作用正在逐渐扩大，特别是在检测冠状动脉疾病（其准确性比SPECT高约10 - 15%）和评估心肌活力方面。核医学与X射线CT成像相结合的最新发展为心脏成像研究提供了更好的衰减校正。很明显，核医学技术在心脏护理和临床诊断中发挥着日益重要的作用。然而，迫切需要改进这些成像模式的性能，以充分发挥其潜力。这项工作的目标是研究一种用于核医学的新的高分辨率探测器。