Simultaneous PET-MR Small Animal Imaging

同步 PET-MR 小动物成像

• 批准号: 7906390
• 负责人: GERALD ENTINE
• 金额: $ 14.94万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7906390
• 关键词: Address; Affect; Anatomy; Animals; Area; Biological; Biological Process; Brain Mapping; Brain Neoplasms; Caliber; California; Cardiac; Ceramics; Charge; Cherry - dietary; Collaborations; Collection; Contrast Media; Coupled; Coupling; Custom; Data; Data Collection; Detection; Development; Devices; Doctor of Philosophy; Dose; Electronics; Elements; Energy-Generating Resources; Environment; Evaluation; Event; Face; FarGo; Fiber; Floods; Gamma Rays; Germany; Goals; Healthcare; Heating; Hybrids; Image; Imaging Phantoms; Indium; Investigation; LSO crystal; Label; Laboratories; Lead; Length; Light; Longitudinal Studies; Magnetic Resonance Imaging; Magnetism; Measurement; Measures; Metabolism; Metals; Modality; Modeling; Nature; Noise; Optics; Organism; Pathway interactions; Performance; Phase; Physics; Physiologic pulse; Positioning Attribute; Positron-Emission Tomography; Principal Investigator; Process; Production; Radiation; Radio; Radiolabeled; Reading; Regulation; Research; Resolution; Running; Scheme; Semiconductors; Sensory Receptors; Services; Signal Transduction; Silicon; Slice; Source; Specimen; System; Technology; Temperature; Testing; Thick; Three-Dimensional Image; Time; Tube; Tumor Biology; Universities; Validation; Weight; Width; abstracting; base; cost; design; detector; drug distribution; flexibility; imaging modality; imaging probe; improved; in vivo; instrument; magnetic field; metal oxide; meter; molecular imaging; neoplastic cell; oncology; optical fiber; photomultiplier; prevent; prototype; public health relevance; radiotracer; response; soft tissue; solid state; tumor

DESCRIPTION (provided by applicant): Simultaneous PET-MR Small Animal Imaging Principal Investigator: Dr. Gerald Entine, Ph.D. Abstract: The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radio labeled probes. Unfortunately, precise signal localization can be extremely difficult due to low spatial resolution and the lack of anatomical information. Magnetic Resonance Imaging (MRI) can provide high spatial resolution and excellent soft tissue contrast, but suffers from poor signal strength leading to low sensitivity. The overall goal of the proposed effort is to combine the best features of PET and MR modalities for small animal studies into a single, very high performance imaging instrument that will record data in both imaging modalities simultaneously. The most obvious benefit of the integrated system will be to provide high-resolution anatomical context for small-animal PET studies. This will lead to better overall understanding of the origin of the PET signals. The 'in-register' MR images can be used to estimate partial volume errors in the lower-resolution PET scans, thus aiding quantification of the PET signal. To achieve these objectives, a high resolution, high sensitivity PET system will be designed and built and will be tested first on a bench, followed by detailed evaluation inside a commercial small animal MR imaging system.

描述(申请人提供)：同步正电子发射计算机断层扫描-磁共振小动物成像首席研究员：杰拉尔德·恩廷博士 摘要： 理想的生物成像系统将提供生命系统的非侵入性、高分辨率、高灵敏度、三维(3D)图像。正电子发射断层扫描(PET)通过使用靶向放射性标记探针提供了对一系列生物过程的高灵敏度。不幸的是，由于低空间分辨率和缺乏解剖信息，精确的信号定位可能是极其困难的。磁共振成像(MRI)可以提供高空间分辨率和良好的软组织对比度，但信号强度低导致敏感性低。拟议工作的总体目标是将用于小动物研究的PET和MR模式的最佳功能结合到一个单独的、非常高性能的成像仪器中，该仪器将同时记录这两种成像模式的数据。集成系统最明显的好处将是为小动物PET研究提供高分辨率的解剖学背景。这将有助于更好地全面了解PET信号的来源。在较低分辨率的正电子发射计算机断层扫描中，“对准”磁共振图像可以用来估计部分体积误差，从而有助于正电子发射计算机断层扫描信号的量化。为了实现这些目标，将设计和制造一个高分辨率、高灵敏度的PET系统，并首先在工作台上进行测试，然后在商业小动物MR成像系统中进行详细的评估。