Simultaneous PET-MR Small Animal Imaging

同步 PET-MR 小动物成像

• 批准号: 7906390
• 负责人: GERALD ENTINE
• 金额: $ 14.94万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7906390
• 关键词: Address; Affect; Anatomy; Animals; Area; Biological; Biological Process; Brain Mapping; Brain Neoplasms; Caliber; California; Cardiac; Ceramics; Charge; Cherry - dietary; Collaborations; Collection; Contrast Media; Coupled; Coupling; Custom; Data; Data Collection; Detection; Development; Devices; Doctor of Philosophy; Dose; Electronics; Elements; Energy-Generating Resources; Environment; Evaluation; Event; Face; FarGo; Fiber; Floods; Gamma Rays; Germany; Goals; Healthcare; Heating; Hybrids; Image; Imaging Phantoms; Indium; Investigation; LSO crystal; Label; Laboratories; Lead; Length; Light; Longitudinal Studies; Magnetic Resonance Imaging; Magnetism; Measurement; Measures; Metabolism; Metals; Modality; Modeling; Nature; Noise; Optics; Organism; Pathway interactions; Performance; Phase; Physics; Physiologic pulse; Positioning Attribute; Positron-Emission Tomography; Principal Investigator; Process; Production; Radiation; Radio; Radiolabeled; Reading; Regulation; Research; Resolution; Running; Scheme; Semiconductors; Sensory Receptors; Services; Signal Transduction; Silicon; Slice; Source; Specimen; System; Technology; Temperature; Testing; Thick; Three-Dimensional Image; Time; Tube; Tumor Biology; Universities; Validation; Weight; Width; abstracting; base; cost; design; detector; drug distribution; flexibility; imaging modality; imaging probe; improved; in vivo; instrument; magnetic field; metal oxide; meter; molecular imaging; neoplastic cell; oncology; optical fiber; photomultiplier; prevent; prototype; public health relevance; radiotracer; response; soft tissue; solid state; tumor

DESCRIPTION (provided by applicant): Simultaneous PET-MR Small Animal Imaging Principal Investigator: Dr. Gerald Entine, Ph.D. Abstract: The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radio labeled probes. Unfortunately, precise signal localization can be extremely difficult due to low spatial resolution and the lack of anatomical information. Magnetic Resonance Imaging (MRI) can provide high spatial resolution and excellent soft tissue contrast, but suffers from poor signal strength leading to low sensitivity. The overall goal of the proposed effort is to combine the best features of PET and MR modalities for small animal studies into a single, very high performance imaging instrument that will record data in both imaging modalities simultaneously. The most obvious benefit of the integrated system will be to provide high-resolution anatomical context for small-animal PET studies. This will lead to better overall understanding of the origin of the PET signals. The 'in-register' MR images can be used to estimate partial volume errors in the lower-resolution PET scans, thus aiding quantification of the PET signal. To achieve these objectives, a high resolution, high sensitivity PET system will be designed and built and will be tested first on a bench, followed by detailed evaluation inside a commercial small animal MR imaging system.

描述（由申请人提供）：同步PET-MR小动物成像主要研究者：Gerald Entine博士，Ph.D。