FREQUENCY-DOMAIN TISSUE SPECTROMETER

频域组织光谱仪

• 批准号: 3505492
• 负责人: Beniamino Barbieri
• 金额: $ 5万
• 依托单位: ISS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3505492
• 关键词: biomedical equipment development; oxygen tension; spectrometry; tissues

We are developing a novel kind of tissue spectrometer, which utilizes total scattered light to quantitatively and non-invasively measure the absorption and scattering coefficients in highly scattering media. The method is based on the use of a radio frequency-modulated light source. Measurement of phase shift and demodulation ratio are used to independently determine the scattering and absorption coefficients along the average path traveled by light in the tissue between this source and a detector. In our apparatus, the phase and demodulation can be accurately measured in real time on a millisecond time base. The important field of application of this tissue spectrometer is in medicine for measuring low concentrations of absorbing metabolites in tissues. In the proposed prototype, the modulated source consists of an array of laser diodes emitting at selected wavelengths relevant to the oxygenation state of the tissue. During Phase I of this project, a prototype instrument for research purposes will be assembled and tested both for integration of new components and limits of the technology. In Phase II absorption and scattering coefficients at different tissue locations will allow imaging of optical properties of tissues. Clinical tests will be performed at the end of Phase II.

我们正在开发一种新型的组织光谱仪， 总散射光定量和非侵入性地测量 高散射介质中的吸收和散射系数。的 该方法基于射频调制光源的使用。 相移和解调比的测量用于 独立地确定沿着的散射和吸收系数 光在该光源和该光源之间的组织中行进的平均路径， 探测器。在我们的装置中，相位和解调可以准确地 以毫秒时间为基准以真实的时间测量。的重要领域 该组织光谱仪在医学上的应用是测量低 组织中吸收代谢物的浓度。拟议 原型，调制源由激光二极管阵列组成 在与所述细胞的氧合状态相关的选定波长下发射， 组织.在该项目的第一阶段， 研究目的将被组装和测试，以整合新的 技术的组成部分和局限性。在第二阶段吸收和 不同组织位置处的散射系数将允许成像 组织的光学特性。临床试验将在 第二阶段结束。