Functional Near Infrared Imaging System

描述（由申请人提供）：ISS将开发一种新型仪器， 大脑功能激活的非侵入性成像。系统将 由新颖的硬件和软件组成。硬件将包括32个激光器 二极管发射器和8个光电倍增管检测器。的新颖特征 硬件将包括一个定制的频率合成器和一个定制的数据 采集卡，这两个将显着提高成像性能 目前的设备。该软件将包括真实的时间视频地图， 多种组织特性（血红蛋白氧饱和度、血红蛋白 浓度和组织光学参数）。这些地图将生成 从包括校准频域多路复用 距离（C-FDMD）方法，绝对频域多距离方法， 连续波差分路径长度法和交叉源检测器 (CSD)路径法这种方法的多样性将使地图， 从每种方法的特点，从高定量的 C-FDMD方法以CSD方法的高度本地化。该系统将 在幻影上进行测试，并在人类受试者中结合功能性 磁共振成像（fMRI）。在完成设计和测试后， 该系统将是世界上唯一的商用研究系统， 红外组织血红蛋白动态成像 拟定商业应用： 1. 脑激活的光学成像和受刺激脑细胞聚集体的定位; 2. 认知神经科学; 3. 心脏搭桥手术中的脑氧合监测 4. 睡眠呼吸暂停研究; 5. 注意力缺陷障碍调查

DESCRIPTION (Provided by Applicant): ISS will develop a novel instrument for the non-invasive imaging of functional activation of the brain. The system will consist of novel hardware and software. The hardware will include 32 laser diode emitters, and 8 photomultiplier tube detectors. Novel features of the hardware will include a customized frequency synthesizer and a customized data acquisition card, both of which will significantly improve imaging performance over current equipment. The software will include real time video maps of multiple tissue properties (hemoglobin oxygen saturation, hemoglobin concentration, and tissue optical parameters). These maps will be generated from a variety of methods including calibrated frequency domain multiple distance (C-FDMD) method, absolute frequency domain multiple distance method, continuous wave differential path length method, and crossed source-detector (CSD) path method. This multiplicity of methods will allow maps which benefit from the special characteristics of each method, from the high quantitation of C-FDMD method to the high localization of the CSD method. The system will be tested on phantoms, and in human subjects in conjunction with functional Magnetic Resonance Imaging (fMRI). Upon completion of its design and test, the system will be the world's only commercially available research system for near infrared tissue hemoglobin dynamics imaging. PROPOSED COMMERCIAL APPLICATION: 1. Optical imaging of brain activation and localization of stimulated brain cellular aggregates; 2. Cognitive neuroscience; 3. Brain oxygenation monitoring during cardiac bypass surgery; 4. Sleep-apnea studies; 5. Attention deficit disorder investigations