FREQUENCY DOMAIN TISSUE SPECTROMETER

频域组织光谱仪

• 批准号: 2546596
• 负责人: Beniamino Barbieri
• 金额: $ 28.14万
• 依托单位: ISS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1999-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2546596
• 关键词: biomedical equipment development; cardiovascular disorder diagnosis; clinical biomedical equipment; clinical research; diagnosis design /evaluation; early diagnosis; fiber optics; hemoglobin; human subject; laser spectrometry; light scattering; noninvasive diagnosis; oxygen transport; peripheral blood vessel disorder; respiratory oxygenation

During Phase I, we developed and built a compact, portable, Frequency- Domain Tissue Spectrometer. The instrument provides, in real time, the absolute values of the scattering and absorption coefficients of oxy- and deoxy-hemoglobin in tissues and, hence, the hemoglobin saturation and the total hemoglobin content. Selected researchers used the instrument for the study of tissue oxygenation in muscles of normal and dystrophic subjects, brain region, for the mapping of the optical parameters of breast and the study of peripheral vascular disease (PVD). Of the many potential applications of the new instrument, we choose the early detection of PVD for the Phase II continuation of this project. This choice is dictated by the importance of the problem and by the successful use of the instrument for PVD early detection during clinical tests. During the Phase II, IFS intends to expand the instrument capabilities, perform exhaustive laboratory tests, and build a clinical instrument for the study and the early detection of PVD. Practical feedback for the instrument development will be provided by climb studies conducted at the University of Texas, Dallas; research aspects related to the interaction of light with tissues will be studied at the University of Illinois at Urbana-Champaign. PROPOSED COMMERCIAL APPLICATION: Non-invasive, absolute measurement of oxygenation state of tissues and determination of blood volume. Determination of tissue absorption and scattering coefficients for accurate setting of laser power in surgery and photodynamic therapy. Assessment of drug delivery to target tissues.

在第一阶段，我们开发和建造了一个紧凑、便携的频率- 域组织光谱仪。该仪器实时提供 氧和氧的散射系数和吸收系数的绝对值 组织中的脱氧血红蛋白，因此，血红蛋白饱和度和 总血红蛋白含量。选定的研究人员使用该仪器进行 正常和营养不良肌肉组织氧合作用的研究 受试者，大脑区域，用于绘制光学参数图 乳房和周围血管疾病(PVD)的研究。在众多人中 新仪器的潜在应用，我们选择了早期的 本项目第二阶段续建工程的PVD检测。这 选择取决于问题的重要性和成功与否 在临床试验中使用该仪器进行PVD的早期检测。 在第二阶段，综合框架打算扩大仪器的能力， 进行详尽的实验室测试，并建立临床仪器 PVD的研究和早期发现。实用的反馈意见 仪器的开发将由在 得克萨斯大学，达拉斯；与互动相关的研究方面 伊利诺伊大学将研究光与组织的关系 乌尔巴纳-香槟。 建议的商业应用：非侵入性、绝对测量 组织氧合状态和血容量的测定。 组织吸收系数和散射系数的测定 手术和光动力疗法中激光功率的准确设置。 对靶组织药物输送的评估。