FREQUENCY DOMAIN TISSUE SPECTROMETER

在第一阶段，我们开发和建造了一个紧凑，便携式，频率- 域组织光谱仪。该仪器真实的时间提供 的散射和吸收系数的绝对值的氧和 组织中的脱氧血红蛋白，因此，血红蛋白饱和度和 总血红蛋白含量。 选定的研究人员使用该仪器， 正常和营养不良肌肉组织氧合研究 受试者，大脑区域，用于映射的光学参数 乳腺和周围血管疾病（PVD）的研究。的许多 新仪器的潜在应用，我们选择早期 检测PVD，以继续该项目的第二阶段。 这 选择取决于问题的重要性和成功的 在临床试验期间使用仪器进行PVD早期检测。 在第二阶段，IFS打算扩大仪器能力， 进行详尽的实验室测试，并建立一个临床仪器， PVD的研究和早期发现。 实用反馈 仪器的研制将由在 得克萨斯大学，达拉斯;与相互作用有关的研究方面 光与组织的关系将在伊利诺伊大学进行研究， 厄巴纳-香槟 拟议的商业应用：无创、绝对测量 组织的氧合状态和血容量的测定。 组织吸收和散射系数的测定 在手术和光动力治疗中精确设置激光功率。 评估药物向靶组织的递送。

During Phase I, we developed and built a compact, portable, Frequency- Domain Tissue Spectrometer. The instrument provides, in real time, the absolute values of the scattering and absorption coefficients of oxy- and deoxy-hemoglobin in tissues and, hence, the hemoglobin saturation and the total hemoglobin content. Selected researchers used the instrument for the study of tissue oxygenation in muscles of normal and dystrophic subjects, brain region, for the mapping of the optical parameters of breast and the study of peripheral vascular disease (PVD). Of the many potential applications of the new instrument, we choose the early detection of PVD for the Phase II continuation of this project. This choice is dictated by the importance of the problem and by the successful use of the instrument for PVD early detection during clinical tests. During the Phase II, IFS intends to expand the instrument capabilities, perform exhaustive laboratory tests, and build a clinical instrument for the study and the early detection of PVD. Practical feedback for the instrument development will be provided by climb studies conducted at the University of Texas, Dallas; research aspects related to the interaction of light with tissues will be studied at the University of Illinois at Urbana-Champaign. PROPOSED COMMERCIAL APPLICATION: Non-invasive, absolute measurement of oxygenation state of tissues and determination of blood volume. Determination of tissue absorption and scattering coefficients for accurate setting of laser power in surgery and photodynamic therapy. Assessment of drug delivery to target tissues.