Use of quinone adducted peptides in the regulation of fertility

醌加合肽在生育力调节中的用途

• 批准号: DP150103231
• 负责人: Prof Robert Aitken
• 金额: $ 27.83万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-02-16 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150103231
• 关键词: Use; quinone; adducted; peptides; regulation

This project describes a novel strategy for the non-surgical induction of sterility in male and female mammals with applications in the fields of biotechnology, veterinary medicine and the humane control of pest animal species. The approach is dependent upon the known sensitivity of the germ line to oxidative stress. The strategy rests upon the demonstration that quinone-adducted peptides will selectively bind to non-renewable cell types in the ovary and testis and redox cycle at the cell surface generating a highly localised state of oxidative stress. This stress will then recapitulate the impact of radiation on reproductive tissues by selectively compromising the viability of the germ line, inducing a state of sterility.

该项目描述了一种非手术诱导雄性和雌性哺乳动物不育的新策略，可应用于生物技术、兽医学和有害动物物种的人道控制领域。该方法依赖于已知的生殖系对氧化应激的敏感性。该策略依赖于证明醌加合肽将选择性地与卵巢和睾丸中的不可再生细胞类型结合，并在细胞表面产生高度局部化的氧化应激状态的氧化还原循环。然后，这种压力将通过选择性地损害生殖系的活力，诱发不育状态，再现辐射对生殖组织的影响。