Use of quinone adducted peptides in the regulation of fertility

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This project describes a novel strategy for the non-surgical induction of sterility in male and female mammals with applications in the fields of biotechnology, veterinary medicine and the humane control of pest animal species. The approach is dependent upon the known sensitivity of the germ line to oxidative stress. The strategy rests upon the demonstration that quinone-adducted peptides will selectively bind to non-renewable cell types in the ovary and testis and redox cycle at the cell surface generating a highly localised state of oxidative stress. This stress will then recapitulate the impact of radiation on reproductive tissues by selectively compromising the viability of the germ line, inducing a state of sterility.