Modulation of telomere length and subtelomeric DNA methylation in response to oxidative stress in the male germ line; implications for tumorigenesis in the offspring

雄性种系氧化应激反应中端粒长度和亚端粒 DNA 甲基化的调节；

• 批准号: nhmrc : 1047776
• 负责人: Prof Robert Aitken
• 金额: $ 20.72万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-telomere-length-tumorigenesis-offspring/111969
• 关键词: Modulation; telomere; length; subtelomeric; DNA

This research project is designed to elucidate how the quality of a father’s spermatozoa can impact upon the health and wellbeing of his children. We hypothesize that factors, such as infertility, heavy smoking or age create a state of oxidative stress in the testes and that this stress influences the genetic structure of spermatozoa in such a way that the incidence of spontaneous mutations and susceptibility-to-cancer are significantly elevated in the offspring.

本研究项目旨在阐明父亲精子的质量如何影响其子女的健康和福祉。我们假设，因素，如不孕症，大量吸烟或年龄在睾丸中产生氧化应激状态，这种应激影响精子的遗传结构，以这种方式，自发突变和易感性的发生率显着升高的后代癌症。