MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

福克斯·蔡斯癌症中心癌症研究所希望 购买一台瓦里安200 MHz核磁共振光谱仪。仪器将会是 作为现有光谱学支持设施的一部分运行。这个 光谱仪将解决小分子、分析八个核磁共振的需求 独立调查人员以及有机组织的要求 福克斯·蔡斯癌症中心的化学和多肽合成设施。 所有用户都有受资助的基础生物医学研究项目 通过积极的同行评议的研究拨款。这些研究项目涵盖了 广泛的化学和生物化学主题，包括药物设计， 天然产物分析、酶学和蛋白质结构、动力学和 功能。大多数依赖于有效确定结构的能力 和/或小分子的同位素含量。此需求当前不是 在福克斯大通校园里与现有的光谱仪相遇。 拟议的仪器将提供一个用户友好的环境，同时 允许广泛的能力，包括观察所有 相关的核和相关的二维核磁共振能力。这个 该文书还将允许开发和实施新的两个 维度核磁共振技术，如果在更高的磁场上进行 仪器，将严重阻碍分光计的有效使用 致力于蛋白质核磁共振波谱。建议的主要重点是 光谱仪易于接近，并具有足够的复杂性 允许快速测定小分子的结构。

The Institute for Cancer Research, Fox Chase Cancer Center, desires to purchase a Varian 200 MHz NMR spectrometer. The instrument will be operated as part of an existing spectroscopy support facility. The spectrometer will address the small molecule, analytical NMR needs of eight independent investigators as well as the requirements of the Organic Chemistry and Peptide Synthesis Facility of the Fox Chase Cancer Center. All users have programs in basic biomedical research that are funded through active peer reviewed research grants. These research programs span a broad range of chemical and biochemical topics including drug design, natural product analysis, enzymology and protein structure, dynamics and function. Most rely on the ability to efficiently determine the structure and/or isotopic content of small molecules. This demand is not currently being met by the existing spectrometers on the Fox Chase campus. The proposed instrument will provide a user friendly environment while allowing a broad spectrum of capabilities including observation of all relevant nuclei and pertinent two dimensional NMR capabilities. The instrument will also allow the development and implementation of new two dimensional NMR techniques that, if carried out on higher field instruments, would severely hinder the efficient use of spectrometers dedicated to protein NMR spectroscopy. The prime emphasis of the proposed spectrometer is ease of access combined with sufficient sophistication to allow the rapid determination of the structure of small molecules.