MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

福克斯蔡斯癌症中心癌症研究所希望 购买Varian 200 MHz NMR光谱仪。 仪器将 作为现有光谱支持设施的一部分运行。 的 光谱仪将解决小分子，分析核磁共振需要的八个 独立调查人员以及有机要求 化学和肽合成设施的福克斯大通癌症中心。 所有用户都有基础生物医学研究项目， 通过积极的同行评审研究赠款。 这些研究项目跨越 广泛的化学和生物化学主题，包括药物设计， 天然产物分析，酶学和蛋白质结构，动力学和 功能 大多数依赖于有效确定结构的能力 和/或小分子的同位素含量。 目前，这一需求并不 福克斯蔡斯校园里现有的光谱仪。 拟议的仪器将提供一个用户友好的环境， 允许广泛的能力，包括观察所有 相关的核和相关的二维NMR能力。 的 该工具还将允许开发和实施新的两个 三维核磁共振技术，如果在更高的领域进行， 仪器，将严重阻碍光谱仪的有效使用 致力于蛋白质核磁共振光谱学。 建议的主要重点是 光谱仪易于使用， 可以快速测定小分子的结构。

The Institute for Cancer Research, Fox Chase Cancer Center, desires to purchase a Varian 200 MHz NMR spectrometer. The instrument will be operated as part of an existing spectroscopy support facility. The spectrometer will address the small molecule, analytical NMR needs of eight independent investigators as well as the requirements of the Organic Chemistry and Peptide Synthesis Facility of the Fox Chase Cancer Center. All users have programs in basic biomedical research that are funded through active peer reviewed research grants. These research programs span a broad range of chemical and biochemical topics including drug design, natural product analysis, enzymology and protein structure, dynamics and function. Most rely on the ability to efficiently determine the structure and/or isotopic content of small molecules. This demand is not currently being met by the existing spectrometers on the Fox Chase campus. The proposed instrument will provide a user friendly environment while allowing a broad spectrum of capabilities including observation of all relevant nuclei and pertinent two dimensional NMR capabilities. The instrument will also allow the development and implementation of new two dimensional NMR techniques that, if carried out on higher field instruments, would severely hinder the efficient use of spectrometers dedicated to protein NMR spectroscopy. The prime emphasis of the proposed spectrometer is ease of access combined with sufficient sophistication to allow the rapid determination of the structure of small molecules.