MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

福克斯蔡斯癌症中心癌症研究所希望 购买 Varian 200 MHz NMR 波谱仪。 该仪器将是 作为现有光谱支持设施的一部分运行。 的 光谱仪将满足八种小分子、分析核磁共振的需求 独立调查员以及有机组织的要求 福克斯蔡斯癌症中心的化学和肽合成设施。 所有用户都有受资助的基础生物医学研究项目 通过积极的同行评审研究资助。 这些研究项目涵盖 广泛的化学和生物化学主题，包括药物设计、 天然产物分析、酶学和蛋白质结构、动力学和 功能。 大多数依赖于有效确定结构的能力 和/或小分子的同位素含量。 目前还没有这个需求 福克斯蔡斯园区现有的光谱仪可以满足这一要求。 拟议的仪器将提供一个用户友好的环境，同时 允许广泛的功能，包括观察所有 相关的原子核和相关的二维核磁共振功能。 的 工具还将允许开发和实施新的两个 三维核磁共振技术，如果在更高的领域进行 仪器，将严重阻碍光谱仪的有效使用 致力于蛋白质核磁共振波谱。 拟议的主要重点 光谱仪易于使用且足够复杂，可以 允许快速测定小分子的结构。

The Institute for Cancer Research, Fox Chase Cancer Center, desires to purchase a Varian 200 MHz NMR spectrometer. The instrument will be operated as part of an existing spectroscopy support facility. The spectrometer will address the small molecule, analytical NMR needs of eight independent investigators as well as the requirements of the Organic Chemistry and Peptide Synthesis Facility of the Fox Chase Cancer Center. All users have programs in basic biomedical research that are funded through active peer reviewed research grants. These research programs span a broad range of chemical and biochemical topics including drug design, natural product analysis, enzymology and protein structure, dynamics and function. Most rely on the ability to efficiently determine the structure and/or isotopic content of small molecules. This demand is not currently being met by the existing spectrometers on the Fox Chase campus. The proposed instrument will provide a user friendly environment while allowing a broad spectrum of capabilities including observation of all relevant nuclei and pertinent two dimensional NMR capabilities. The instrument will also allow the development and implementation of new two dimensional NMR techniques that, if carried out on higher field instruments, would severely hinder the efficient use of spectrometers dedicated to protein NMR spectroscopy. The prime emphasis of the proposed spectrometer is ease of access combined with sufficient sophistication to allow the rapid determination of the structure of small molecules.