POTENTIAL ANTI-TUMOR TRANSITION METAL COMPLEXES

潜在的抗肿瘤过渡金属配合物

• 批准号: 3877338
• 负责人: MARIEL M MUIR
• 金额: --
• 依托单位: UNIVERSITY OF PUERTO RICO RIO PIEDRAS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3877338
• 关键词: X ray crystallography; antineoplastics; chemical structure function; drug design /synthesis /production; gold; ions; isomer; ligands; metal complex; nucleosides; nucleotides; palladium; platinum; rhodium; stereochemistry

Transition metal complexes of platinum(II), palladium(II), platinum(IV), gold(I), gold(III), rhodium(III), iridium(III), and lower oxidation states of rhodium and iridium will be prepared and evaluated for anti-tumor activity. A wide variety of ligands will be used, including ligands which also exhibit anti-tumor activity without complexation to the metal. X-ray structural studies will be carried out. The properties of the complexes in solution and their interactions with nucleobases and other biologically important molecules will be studied. Products of these interactions which can be crystallized will be subjected to X-ray structural analysis.

铂（II）、钯（II）、