POTENTIAL ANTI-TUMOR TRANSITION METAL COMPLEXES

潜在的抗肿瘤过渡金属配合物

• 批准号: 3915710
• 负责人: MARIEL M MUIR
• 金额: --
• 依托单位: UNIVERSITY OF PUERTO RICO RIO PIEDRAS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3915710
• 关键词: X ray crystallography; antineoplastics; chemical structure function; drug design /synthesis /production; gold; ions; isomer; ligands; metal complex; nucleosides; nucleotides; palladium; platinum; rhodium; stereochemistry

Transition metal complexes of platinum(II), palladium(II), platinum(IV), gold(I), gold(III), rhodium(III), iridium(III), and lower oxidation states of rhodium and iridium will be prepared and evaluated for anti-tumor activity. A wide variety of ligands will be used, including ligands which also exhibit anti-tumor activity without complexation to the metal. X-ray structural studies will be carried out. The properties of the complexes in solution and their interactions with nucleobases and other biologically important molecules will be studied. Products of these interactions which can be crystallized will be subjected to X-ray structural analysis.

铂（II），钯（II）， 铂（IV）、金（I）、金（III）、铑（III）、铱（III）和 将制备较低氧化态的铑和铱， 评估抗肿瘤活性。 各种各样的配体将 包括也表现出抗肿瘤活性的配体 而不与金属络合。 X射线结构研究将 执行。 研究了配合物在溶液中的性质， 它们与核碱基和其他生物学上 重要的分子将被研究。 这些产品 可以结晶的相互作用将受到X射线的照射 结构分析