METAL ION COMPLEXATION

这项研究的目的是定量地确定 三价稀土阳离子的配位和络合性质， 以及随后这些信息在这些研究中的应用 具有重要生理意义的配体的离子。使用的是镧系元素 广泛用作核磁共振(NMR)化学位移试剂，AS 生物系统的探针，需要金属离子才能起作用，如结合 具有离子载体和生物配体的试剂，以及在许多工业领域 流程。查找的信息包括最大协调数 在我们的测量条件下；如果有变化的话， 通过镧系元素的这种价值；竞争的程度 溶剂化及其与配位体性质的相关性； 内壳层络合及其对阴离子和溶剂性质的依赖； 在所有情况下，对结构的定量测定 溶液中的物种。 所使用的实验技术允许直接观察核磁共振 初级阳离子溶剂化壳层中的组分的信号， 具体地说，溶剂配体、阴离子，在某些体系中，金属离子 本身，例如，镧。反过来，这些观察结果又导致了 上述稀土配位性能的定量评价 上面。测量将使用布鲁克AM-400多核计算机进行， 超导傅里叶变换核磁共振波谱仪。根据盐的不同 和溶剂体系，化学位移、面积和线宽技术以 将涉及1H、13C、15N、31P、35CL、81Br、127I和金属- 在可能的情况下，离子核。对其中的大多数进行可行性测量 原子核已经制造出来了。

The objectives of this research are the quantitative determination of the coordination and complexing properties of the trivalent lanthanide cations, and the subsequent application of this information to the study of these ions with ligands of physiological importance. the lanthanides are used extensively as nuclear magnetic resonance (NMR) chemical shift reagents, as probes of biological systems requiring a metal-ion for activity, as binding agents with ionophores and biological ligands, and in numerous industrial processes. The information sought includes the maximum coordination number at our conditions of measurement; the determination of variations, if any, of this value through the lanthanide series; the extent of competitive solvation and its correlation with ligand properties; the presence of inner-shell complexing and its dependence on anion and solvent properties; and in all cases, the quantitative determination of the structures of the species in solution. The experimental techniques to be used permit the direct observation of NMR signals for the components in the primary cation solvation shell, specifically, solvent ligands, anions, and in some systems, the metal ion itself, for example, lanthanum. In turn, these observations lead to the quantitative evaluation of the lanthanide coordination properties mentioned above. The measurements will be made using a Bruker AM-400 multinuclear, superconducting, Fourier transform NMR spectrometer. Depending on the salt and solvent system, the chemical shift, area, and linewidth techniques to be applied will involve the 1H, 13C, 15N, 31P, 35Cl, 81Br, 127I, and metal- ion nuclei where possible. Feasibility measurements with most of these nuclei have already been made.