Multidimensional and Multiparametric Quantitative Cardiac MRI from Continuous Free-Breathing Acquisition

连续自由呼吸采集的多维和多参数定量心脏 MRI

• 批准号: EP/P032311/1
• 负责人: Claudia Prieto
• 金额: $ 72.07万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP032311%2F1
• 关键词: Multidimensional; Multiparametric; Quantitative; Cardiac; MRI

Cardiovascular disease (CVD) is the leading single cause of morbidity and mortality in the Western world, causing over 65.000 deaths every year in England. Improving the treatment and outcome of cardiovascular disease is one of the main priorities of the National Health Service (NHS) and a reduction of 25% in mortality associated to cardiovascular disease by the year 2025 is one of the major challenges proposed by the United Nations. Magnetic Resonance Imaging (MRI) is a very promising non-invasive tool for early risk assessment, guidance of therapy and treatment monitoring of CVD. MRI has been shown to provide exquisite depiction of cardiac anatomy and is considered the gold standard to assess ventricular volumes and function. More recently, quantitative mapping of magnetic relaxation properties (known as e.g. T1 and T2 relaxation times) have been developed to standardise the quantitative measurement of myocardial tissue properties, enabling non-invasive characterisation and differentiation of diseased and healthy tissue. Clinical research studies have shown the potential of parametric mapping techniques for quantification of diffuse myocardial fibrosis (T1 map) and the assessment of myocardial oedema and inflammation (T2 map). Thus, MR parameter mapping offer the promise of early disease detection and monitoring over time or in response to therapy, changing the MR paradigm from visualisation to quantification.The limitation of the current MRI scheme is that all these images (e.g. cardiac anatomy, function, T1 map and T2 map) are acquired sequentially, usually with different resolution, different geometric orientations and at different breath-hold positions. This scheme requires patient cooperation as acquisitions are usually performed under multiple breath holds, requires experienced radiographers to plan and perform the different acquisitions, and results in long scan times. Moreover patients are usually unable to hold their breath at the same respiratory position. Thus images acquired at different breath-holds cannot be directly fused thereby affecting diagnosis, accuracy and reproducibility of cardiac MRI. The method proposed in this project will overcome these problems by allowing the simultaneous acquisition of MR images with multiple parameters (e.g. cardiac anatomy, function, T1 map and T2 map), throughout the whole cardiac and respiratory cycles, from a single free-breathing acquisition. Thus providing anatomic and functional information simultaneously with quantitative information of multiple tissue parameters for an efficient (single scan, shorter and predictable scan time), accurate, simplified (less planning required and more comfortable for the patients) and comprehensive assessment of cardiovascular disease.

心血管疾病 (CVD) 是西方世界发病率和死亡率的首要单一原因，每年在英国造成超过 65,000 人死亡。改善心血管疾病的治疗和结果是英国国家医疗服务体系 (NHS) 的主要优先事项之一，到 2025 年将心血管疾病相关死亡率降低 25% 是联合国提出的主要挑战之一。磁共振成像（MRI）是一种非常有前途的非侵入性工具，可用于心血管疾病的早期风险评估、治疗指导和治疗监测。 MRI 已被证明可以提供心脏解剖结构的精美描述，并被认为是评估心室体积和功能的黄金标准。最近，磁弛豫特性（例如 T1 和 T2 弛豫时间）的定量测​​绘已被开发出来，以标准化心肌组织特性的定量测量，从而能够对患病组织和健康组织进行非侵入性表征和区分。临床研究表明参数绘图技术在量化弥漫性心肌纤维化（T1 图）和评估心肌水肿和炎症（T2 图）方面具有潜力。因此，MR 参数映射提供了随着时间的推移或对治疗的反应进行早期疾病检测和监测的希望，将 MR 范式从可视化改变为量化。当前 MRI 方案的局限性在于，所有这些图像（例如心脏解剖结构、功能、T1 图和 T2 图）都是按顺序采集的，通常具有不同的分辨率、不同的几何方向和不同的屏气位置。该方案需要患者合作，因为采集通常在多次屏气下进行，需要经验丰富的放射技师计划和执行不同的采集，并导致扫描时间较长。此外，患者通常无法在同一呼吸位置屏住呼吸。因此，不同屏气时获取的图像无法直接融合，从而影响心脏 MRI 的诊断、准确性和再现性。本项目提出的方法将克服这些问题，通过一次自由呼吸采集，在整个心脏和呼吸周期中同时采集具有多个参数（例如心脏解剖结构、功能、T1 图和 T2 图）的 MR 图像。从而同时提供解剖和功能信息以及多个组织参数的定量信息，从而对心血管疾病进行高效（单次扫描、更短且可预测的扫描时间）、准确、简化（需要更少的计划并且更舒适）和全面的心血管疾病评估。

项目成果

Additional file 5 of 3D whole-heart isotropic sub-millimeter resolution coronary magnetic resonance angiography with non-rigid motion-compensated PROST

使用非刚性运动补偿 PROST 的 3D 全心各向同性亚毫米分辨率冠状动脉磁共振血管造影的附加文件 5

• DOI: 10.6084/m9.figshare.12143913
• 发表时间: 2020
• 作者: Bustin A

Additional file 1 of 3D whole-heart isotropic sub-millimeter resolution coronary magnetic resonance angiography with non-rigid motion-compensated PROST

使用非刚性运动补偿 PROST 的 3D 全心各向同性亚毫米分辨率冠状动脉磁共振血管造影的附加文件 1

• DOI: 10.6084/m9.figshare.12143886
• 发表时间: 2020
• 作者: Bustin A

KomaMRI.jl: An Open-Source Framework for General MRI Simulations with GPU Acceleration

KomaMRI.jl：具有 GPU 加速功能的通用 MRI 模拟开源框架

• DOI: 10.48550/arxiv.2301.02702
• 发表时间: 2023
• 作者: Castillo-Passi C