TR&D1: Ultra-Fast Multiparametric MR Imaging Methods for Quantitative PET/MR

结合定量MR（qMR）与PET协同提供完美的注册， 互补的生理生物标志物。我们在最初的融资周期，Y1-4， 我们的P41在定量PET/MR中的应用，为一些最棘手的问题提供了解决方案 影响PET/MR，包括衰减校正的可靠和准确校正， 主体无意识运动这些技术实现PET分辨率接近固有分辨率 扫描仪的功能，并实现了一系列新颖的PET/MR应用。在此更新申请中，我们将 开发和提供独特的PET/MR成像技术，不仅能够实现生理高， 影响新型PET/MR，但也将有利于独立的MR研究。我们专注于多方面的工作， 通过利用我们最近在子空间/流形建模方面的突破， MR物理学为深度学习（DL）和多对比度超快速MR序列提供了信息。我们提出的 研究集中在开发和提供新的PET/MR成像技术，沿着三个轴：i） 用于运动校正的全心脏膜的多参数、自由运行的心脏MRI方法 使用PET/MR的潜在成像; ii）用于多模态，多参数， 使用PET/MR的分子成像;以及iii）使用深度成像的超快速、多组分定量MR。 学习和MR物理建模。我们将在TR&D3 PET/MR轴上验证所提出的方法 研究和通过与我们的合作项目的合作。我们会利用DL TR&D2中提出的进一步提高定量PET/MR图像质量的方法 在TR&D1技术。

Combining quantitative MR (qMR) with PET synergistically provides perfectly registered, complementary physiological biomarkers. Our pioneering work during the initial funding cycle, Y1-4, of our P41 in quantitative PET/MR, has provided solutions to some of the most vexing problems affecting PET/MR, including reliable and accurate corrections for attenuation correction and involuntary subject motion. These techniques achieve PET resolution close to the intrinsic resolution of the scanner and enable a range of novel PET/MR applications. In this renewal application, we will develop and deliver unique PET/MR imaging technologies that not only enable physiological high- impact novel PET/MR but will also benefit standalone MR research. We focus our efforts on multi- parametric qMR techniques by leveraging our recent breakthroughs on subspace/manifold modeling, MR-physics informed deep learning (DL), and multi-contrast ultra-fast MR sequences. Our proposed research focuses on developing and delivering new PET/MR imaging techniques along three axes: i) multi-parametric, free-running, cardiac MRI method for motion corrected whole-heart membrane potential imaging using PET/MR; ii) high resolution MRSI for multi-modality, multi-parametric, molecular imaging using PET/MR; and iii) ultra-fast, multi-component quantitative MR using deep learning and MR physics modeling. We will validate the proposed methods in TR&D3 PET/MR axes of research and through collaborations with our Collaborative Projects. We will leverage the DL methodologies proposed in TR&D2 to further improve image quality of quantitative PET/MR techniques in TR&D1.