Motion Corrected Reconstruction for 3D Cardiac Simultaneous PET-MR Imaging: Towards Efficient Assessment of Coronary Artery Disease

3D 心脏同步 PET-MR 成像的运动校正重建：实现冠状动脉疾病的有效评估

• 批准号: EP/N009258/1
• 负责人: Claudia Prieto
• 金额: $ 77.56万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN009258%2F1
• 关键词: Motion; Corrected; Reconstruction; 3D; Cardiac

Coronary artery disease (CAD) is the leading single cause of morbidity and mortality in the Western world. CAD reduces the blood supply to the cardiac muscle and can lead to chest pain (angina) or heart attack. CAD diagnosis is currently performed by a wide range of invasive and non-invasive tests. However in current practice a non-negligible number of patients that may not need the intervention are referred to invasive, ionizing, and potentially harmful x-ray cardiac catheterization procedures. Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) are two very promising non-invasive imaging technologies for early risk assessment, guidance of therapy and treatment monitoring of CAD. Both technologies provide complementary information, thus the recent introduction of simultaneous PET-MR systems offers great potential for accurate interpretation of findings of PET and MR images and new perspectives for better CAD diagnosis and treatment. For example three-dimensional fusion of PET perfusion images with non-invasive coronary MR images may allow the exact localization of stenosis, causing ischemia, to guide required interventions. However, inevitable patient motion (such as that caused by breathing and heart beating) during the acquisition degrades the image quality of both PET and MR images. Currently, commercial simultaneous PET-MR scanners do not feature technology for efficient and accurate correction of such motion. Current research developments that deal with the motion problem in cardiovascular PET-MR concentrate mainly on improving the quality of PET images based on MR information. Moreover these approaches do not allow truly simultaneous PET and MR acquisitions leading to prolonged scan times, since diagnostic MR images need to be acquired after the simultaneous PET-MR acquisition. The reason is that dedicated MR acquisitions need to be performed concurrently with the PET imaging in order to correct for motion in the PET data. This means that MR is being used as an expensive motion-correction device limiting its diagnostic utility. In this proposal we aim to develop, implement and test the clinical feasibility of an efficient PET-MR acquisition and reconstruction framework that enables truly simultaneous acquisition of complementary PET and MR diagnostic information. We hypothesize that this can be achieved using synergistic information of both modalities i.e. functional, anatomic and motion MR information, and quantitative perfusion PET data in a motion corrected reconstruction approach. The proposed approach is foreseen as an important step towards clinical adoption of PET-MR cardiovascular imaging and lastly towards an efficient and accurate non-invasive assessment of CAD.

冠状动脉疾病（CAD）是西方世界发病率和死亡率的主要单一原因。CAD减少了心肌的血液供应，并可能导致胸痛（心绞痛）或心脏病发作。CAD诊断目前通过广泛的侵入性和非侵入性测试进行。然而，在目前的实践中，可能不需要干预的不可忽略数量的患者被称为侵入性、电离和潜在有害的X射线心脏导管插入术。磁共振成像（MRI）和正电子发射断层扫描（PET）是两种非常有前途的非侵入性成像技术，用于CAD的早期风险评估、治疗指导和治疗监测。这两种技术提供了互补的信息，因此，最近推出的同步PET-MR系统提供了很大的潜力，准确解释的结果PET和MR图像和新的观点，更好的CAD诊断和治疗。例如，PET灌注图像与非侵入性冠状动脉MR图像的三维融合可以允许引起缺血的狭窄的精确定位，以指导所需的介入。然而，在采集期间不可避免的患者运动（诸如由呼吸和心跳引起的运动）降低PET和MR图像两者的图像质量。目前，商业同步PET-MR扫描仪没有用于有效和准确校正这种运动的技术。目前，针对心血管PET-MR中运动问题的研究主要集中在基于MR信息提高PET图像质量上。此外，这些方法不允许真正同时的PET和MR采集，从而导致延长的扫描时间，因为诊断MR图像需要在同时的PET-MR采集之后被采集。原因在于，需要与PET成像同时执行专用MR采集，以便校正PET数据中的运动。这意味着MR被用作昂贵的运动校正设备，限制了其诊断实用性。在本提案中，我们的目标是开发、实施和测试高效PET-MR采集和重建框架的临床可行性，该框架能够真正同时采集互补的PET和MR诊断信息。我们假设这可以通过使用两种模态的协同信息（即功能、解剖和运动MR信息）以及运动校正重建方法中的定量灌注PET数据来实现。所提出的方法被认为是临床采用PET-MR心血管成像的重要一步，最终实现CAD的有效和准确的非侵入性评估。

项目成果

Optimized respiratory-resolved motion-compensated 3D Cartesian coronary MR angiography.

• DOI: 10.1002/mrm.27208
• 发表时间: 2018-12
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Correia T;Ginami G;Cruz G;Neji R;Rashid I;Botnar RM;Prieto C
• 通讯作者: Prieto C

3D-Patch-Based Low-Rank Reconstruction (PROST) for Highly-Accelerated CMRA Acquisition

用于高加速 CMRA 采集的基于 3D 补丁的低阶重建 (PROST)

• 发表时间: 2018
• 作者: Bustin A

Five-minute whole-heart coronary MRA with sub-millimeter isotropic resolution, 100% respiratory scan efficiency, and 3D-PROST reconstruction.

• DOI: 10.1002/mrm.27354
• 发表时间: 2019-01
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Bustin A;Ginami G;Cruz G;Correia T;Ismail TF;Rashid I;Neji R;Botnar RM;Prieto C
• 通讯作者: Prieto C

Imaging of the Cardiovascular System, Thorax, and Abdomen

心血管系统、胸部和腹部成像

• DOI: 10.1201/b19675-2
• 发表时间: 2016
• 作者: Chiribiri A

Four-Minute Whole-Heart Coronary MRA with Sub-Millimeter Isotropic Resolution and 100% Respiratory Scan Efficiency

四分钟%20全心%20冠状动脉%20MRA%20和%20亚毫米%20各向同性%20分辨率%20和%20100%%20呼吸%20扫描%20效率

• 发表时间: 2018
• 作者: Bustin A