Interlocked fullerene and endohedral metallofullerene hosts for molecular machine-like sensing

用于分子机器传感的互锁富勒烯和内嵌金属富勒烯主体

• 批准号: EP/P033490/1
• 负责人: Paul Beer
• 金额: $ 111.58万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP033490%2F1
• 关键词: Interlocked; fullerene; endohedral; metallofullerene; hosts

Mechanically interlocked molecules such as rotaxanes, which resemble a molecular abacus with rod-like molecules passing through one or more rings and catenanes, which are two or more interpenetrating rings, are firmly established entities in the field of nanoscale molecular machines because of their ability to undergo controlled and reversible molecular motion through changes in the relative positions of their constituent parts. The inherent dynamics of such molecules can be controlled by light, electrochemical and chemical-based stimuli. This proposal aims to exploit their unique topological interlocked host cavities to recognize guest molecules as a means of causing the ring component of a rotaxane or catenane to move from one position to another along an rod-like axle or larger ring component as a sophisticated means of sensing negatively charged species of biological, medical and environmental importance. Through the attachment of nanoscale 'light bulbs' including luminescent metal 'filaments' inside an all carbon sphere-like football, to specific positions on the ring and axle components, the switching on or off of the light bulb is designed to occur when a target negatively charged species is recognised and causes ring components to slide or shuttle from one station position to another. Such materials can be thought of as "molecular machine-like sensors".Coating these materials on to conducting and optically transparent surfaces will produce devices that will change colour and/or emit light and undergo electrochemical perturbation in response to the addition of a specific negatively charged substrate. Fundamentally, the project will add considerable volume to our understanding of how complex molecular architectures, designed to exhibit dynamic motion, respond when confined to the sorts of surfaces that will, ultimately, underpin their application.

机械互锁的分子，如轮烷，其类似于具有穿过一个或多个环的棒状分子的分子算盘，以及索烃，其是两个或更多个互穿环，是纳米级分子机器领域中牢固建立的实体，因为它们能够通过其组成部分的相对位置的变化进行受控和可逆的分子运动。这些分子的固有动力学可以通过光、电化学和化学刺激来控制。该提议旨在利用它们独特的拓扑互锁的主体腔来识别客体分子，作为使轮烷或链烷的环组分沿着沿着棒状轴或更大的环组分从一个位置移动到另一个位置的手段，作为感测生物、医学和环境重要性的带负电荷的物种的复杂手段。通过将包括全碳球形足球内的发光金属“灯丝”的纳米级"灯泡“附接到环和轴部件上的特定位置，灯泡的接通或断开被设计成当识别出目标带负电荷的物质时发生，并导致环部件从一个站位置滑动或穿梭到另一个站位置。这种材料可以被认为是“分子机器样传感器”。将这些材料涂覆在导电和光学透明的表面上将产生响应于添加特定的带负电荷的基底而改变颜色和/或发光并经历电化学扰动的装置。从根本上说，该项目将增加相当大的体积，以我们的理解如何复杂的分子结构，旨在表现出动态运动，当被限制在各种表面，最终将巩固其应用。

项目成果

Engineered Binding Microenvironments in Halogen Bonding Polymers for Enhanced Anion Sensing

用于增强阴离子传感的卤素键合聚合物中的工程结合微环境

• DOI: 10.1002/ange.202300867
• 发表时间: 2023
• 期刊: Angewandte Chemie
• 作者: Bak K

Fullerene-Functionalized Halogen-Bonding Heteroditopic Hosts for Ion-Pair Recognition.

• DOI: 10.1021/jacs.3c07774
• 发表时间: 2023-12-20
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Bak, Krzysztof M.;Marques, Igor;Kuhn, Heike;Christensen, Kirsten E.;Felix, Vitor;Beer, Paul D.
• 通讯作者: Beer, Paul D.