X-RAY FLOURESCENCE SPECTROMETER SYSTEM

X 射线荧光光谱仪系统

• 批准号: 3519960
• 负责人: ROBERT F MATTREY
• 金额: $ 12.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-04 至 1989-04-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519960
• 关键词: X ray spectrometry; biomedical equipment purchase; computer graphics /printing; elements; fluorescence spectrometry; histology

Research programs often make significant advancements when appropriate new analytical and experimental procedures are developed. We have developed and X-ray fluorescence technique for measuring elements in biological tissues that will provide advanced analytical capability which previously has not been possible. To take full advantage of this achievement, we are requesting funds for the purchase of an X-Ray Fluorescence (XRF) Spectrometer system. In the basic operation of an XRF spectroscopy system, a photon bombardment of the sample produces X-rays characteristic for each element which pass through a beryllium window of the sample, strike a detector and are analyzed by a multichannel analyzer. This instrument detects all elements with mol wt greater than 19. The principle investigator developed new techniques utilizing a KEVEX 0700 XRF spectrometer for detecting and quantitating several elements in concentrations greater than 10 umolar, either separately or simultaneously, in various biological tissues. With these technical advances in sample preparation, XRF spectroscopy will simplify many analytical procedures which are now quite tedious and expensive in terms of time and resources. The primary need for the XRF system in our research laboratories is to gain 100% access to the equipment. This instrument will be used in NIH projects related to the development of new contrast enhancement agents for MRI, CT and ultrasonography and for developing new non-invasive MRI diagnostic and physiologic techniques. Current access to the one XRF system in the San Diego region (North Island Naval Base) is limited, inconvenient, terribly inefficient and severely restrictive to the progress of our NIH research programs. When accessible, the XRF system is still only available for a small fraction of the time needed to take full advantage of this technology for our NIH programs. Because of the instrument's versatility and the technical advances we are making in sample preparation, this XRF system will be useful for many years. It will remain an ideal core instrument, suitable for today's important NIH-sponsored projects while flexible enough to be relevant for future projects --- an invaluable tool for reaching today's and tomorrow's research goals.

研究项目通常会取得重大进展， 适当的新的分析和实验程序是 开发 我们开发了X射线荧光技术 用于测量生物组织中的元素， 先进的分析能力，以前没有 可能 为了充分利用这一成就，我们 申请资金购买X射线荧光 (XRF)光谱仪系统。 在XRF的基本操作中， 光谱系统，样品的光子轰击 产生的X射线特征的每个元素，通过 通过样品的铍窗口，撞击检测器， 通过多通道分析仪进行分析。 该仪器检测 摩尔重量大于19的所有元素。 主要研究人员开发了新技术， KEVEX 0700 XRF光谱仪用于检测和定量 浓度大于10微摩尔的几种元素， 单独或同时在不同的生物组织中。 与 这些样品制备技术的进步， 光谱学将简化许多分析程序， 现在在时间和资源方面相当繁琐和昂贵。 我们的研究实验室对XRF系统的主要需求 就是100%地使用设备 该仪器将 用于与开发新对比剂相关的NIH项目 用于MRI、CT和超声检查的增强剂， 开发新的非侵入性MRI诊断和生理 技术. 目前可以访问San Francisco的一个XRF系统 迭戈地区（北岛海军基地）有限，交通不便， 效率极低，严重限制了我们的进步， NIH研究项目。 当可访问时，XRF系统仍然 只有一小部分的时间需要采取充分的 这项技术对我们的NIH项目的优势。 由于仪器的多功能性和技术的进步 我们正在做的样品制备，这个XRF系统将是 多年来有用。 它仍将是一个理想的核心工具， 适用于当今重要的NIH赞助项目， 足够灵活，适用于未来的项目-一个宝贵的 实现今天和明天的研究目标的工具。