Dynamics in DOPC: muon hyperfine coupling constants for an 18:1 delta-9 cis chain

惰性麻醉气体（如Xe和N2O）的作用尚不清楚，特别是这些气体与小分子麻醉中涉及的受体只有微弱的相互作用。一种可能性是通过改变嵌入受体的膜的动力学而产生间接影响。最近在RAL-ISIS μ子设施的实验表明，μ子可以用作用作模型膜的磷脂双层动力学的外部探针。然而，进一步的μ子实验需要在PSI，一个连续的μ子源，为了完成对早期数据的分析，并允许在μ子光谱中看到的变化的完整解释。PSI的实验将产生μ子超精细耦合常数，使磷脂双分子层暴露于Xe或N2O时所见的ALC-MuSR光谱能够完全分配。

The action of inert anaesthetic gases such as Xe and N2O is still unclear, particularly as these will have only weak interactions with receptors implicated in small molecule anaesthesia. One possibility is an indirect effect through changing the dynamics of the membrane in which the receptors are embedded. Recent experiments at the RAL-ISIS muon facility have demonstrated that the muon can be used as an external probe for the dynamics of phospholipid bilayers used as a model membrane. Further muon experiments are however required at PSI, a continuous muon source, in order to complete the analysis of the earlier data and allow a full interpretation of the changes seen in the muon spectra. The experiments at PSI will yield the muon hyperfine coupling constant enabling complete assignment of the ALC-MuSR spectra seen when the phospholipid bilayer is exposed to Xe or N2O.