IRC Next Steps Plus: Photonic Pathogen Theranostics - Point-of-care image guided photonic therapy of bacterial and fungal infection

IRC Next Steps Plus：光子病原体治疗学 - 细菌和真菌感染的护理点图像引导光子疗法

• 批准号: EP/R018669/1
• 负责人: Kev Dhaliwal
• 金额: $ 142.09万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FR018669%2F1
• 关键词: IRC; Next; Steps; Plus; Photonic

Bacterial and fungal infections are responsible for significant death, disability and poor outcomes and are a major financial burden on the health service. Infections resulting from invasive procedures or injuries whereby the body's own defences are breached are common and are now increasing in incidence and severity due to the rise of antimicrobial resistance. In the past, antibiotics were readily able to treat such infections. This research thus addresses, arguably, the biggest challenge facing modern healthcare, the rise of antimicrobial resistance. The post antibiotic era is looming and novel strategies that do not rely upon conventional antibiotics and antifungals are urgently required. This research proposal will develop to near-clinical readiness, novel classes of therapeutic molecules that will bind specifically to microbes for subsequent activation with low energy light to augment microbial killing.Work on the different elements needed to create this technology platform will be undertaken by investigators at Edinburgh and Liverpool Universities in collaboration with partners in India and in a global surgical network. This project will be based in the Proteus interdisciplinary "hub" to ensure rapid product development. The researchers will spend time in each others labs as well as arranging an open network meeting once a year to ensure broader engagement. The scientists (researcher co-investigators) in the proposal who are all early career researchers will benefit significantly from networking and establishing the area of targeted therapeutic delivery for microbial photodynamic therapy.The research will involve Chemists, Production Engineers, NHS Medical Physics, Bioengineers, industrial collaborators and a committed team of senior clinicians (Respiratory and Critical Care Physicians, Surgeons and Ophthalmologists) to co-develop and test the technology in a variety of model systems to demonstrate the widespread applicability in applications that involve surfaces such as the skin, wounds, eyes and in the lung. A key ambition of the research will be to pave the way for subsequent clinical development and as such user (clinical and regulatory) input will be paramount at the inception and development of the technology. The research will develop and foster global links with an ethos of "safe, affordable and scalable" solutions that will then have the highest likelihood of clinical adoption in a variety of healthcare settings. The team will leverage existing capability and expertise in manufacturing, regulatory and commercialisation support to expedite development. In summary, this project will generate; 1) A cutting-edge point of care technology platform which will help patients, doctors and health care workers throughout the world 2) Career development of the early stage researchers 3) Sustainability for the Proteus IRC by launching into targeted therapy of infection 4) Create a sustainable network to disseminate the technology

细菌和真菌感染是造成重大死亡、残疾和不良后果的原因，是卫生服务的主要财政负担。由于侵入性程序或伤害而导致的感染是常见的，由于抗菌素耐药性的增加，感染的发生率和严重性现在都在增加。在过去，抗生素很容易就能治疗这种感染。因此，这项研究可以说解决了现代医疗保健面临的最大挑战，即抗菌素耐药性的上升。后抗生素时代迫在眉睫，迫切需要不依赖传统抗生素和抗真菌药物的新策略。这项研究提案将开发出接近临床准备的新型治疗分子，它们将专门与微生物结合，随后用低能量光激活，以增强微生物的杀灭能力。创建这一技术平台所需的不同元素的工作将由爱丁堡大学和利物浦大学的研究人员与印度和全球外科网络的合作伙伴合作进行。该项目将以Proteus跨学科“枢纽”为基础，以确保快速的产品开发。研究人员将在彼此的实验室中花费时间，并每年安排一次公开的网络会议，以确保更广泛的参与。提案中的科学家(研究人员合作研究人员)都是职业生涯早期的研究人员，他们将从联网和建立微生物光动力疗法的靶向治疗领域中受益匪浅。这项研究将涉及化学家、生产工程师、NHS医学物理学、生物工程师、工业合作者和资深临床医生(呼吸和重症监护医生、外科医生和眼科医生)的坚定团队，共同开发并在各种模型系统中测试该技术，以展示该技术在涉及皮肤、伤口、眼睛和肺部等表面的应用中的广泛适用性。这项研究的一个关键目标将是为随后的临床开发铺平道路，因此用户(临床和监管)的投入在技术的开始和开发中将是至关重要的。这项研究将开发和促进具有“安全、负担得起和可扩展”的解决方案的全球联系，这些解决方案将在各种医疗保健环境中具有最高的临床采用可能性。该团队将利用在制造、监管和商业化支持方面的现有能力和专业知识来加快开发。总而言之，这个项目将产生：1)一个尖端的护理技术平台，将帮助世界各地的患者、医生和卫生保健工作者2)早期研究人员的职业发展3)通过启动感染的靶向治疗为Proteus IRC提供可持续性4)创建一个可持续的网络来传播技术

项目成果

FluoroPi Device With SmartProbes: A Frugal Point-of-Care System for Fluorescent Detection of Bacteria From a Pre-Clinical Model of Microbial Keratitis.

• DOI: 10.1167/tvst.12.7.1
• 发表时间: 2023-07-03
• 期刊: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
• 影响因子: 3
• 作者: Mohanan, Syam Mohan P. C.;Russell, Kay;Duncan, Sheelagh;Kiang, Alex;Lochenie, Charles;Duffy, Emma;Kennedy, Stephnie;Prajna, N. Venkatesh;Williams, Rachel L.;Dhaliwal, Kevin;Williams, Gareth O. S.;Mills, Bethany
• 通讯作者: Mills, Bethany

Red-Shifted Environmental Fluorophores and Their Use for the Detection of Gram-Negative Bacteria

• DOI: 10.3390/chemosensors9060117
• 发表时间: 2021-05
• 期刊: Chemosensors
• 影响因子: 4.2
• 作者: A. Megia-Fernandez;Maxime Klausen;B. Mills;Gillian E. Brown;H. McEwan;N. Finlayson;K. Dhaliwal;M. Bradley

Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy.

• DOI: 10.3390/molecules25225239
• 发表时间: 2020-11-10
• 期刊: Molecules (Basel, Switzerland)
• 作者: Klausen M;Ucuncu M;Bradley M
• 通讯作者: Bradley M