Rapid Fluorescence-based Detection of Bacteria using Quantum Optics

使用量子光学快速基于荧光的细菌检测

• 批准号: EP/R043361/1
• 负责人: M. Carmen Galan
• 金额: $ 7.69万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FR043361%2F1
• 关键词: Rapid; Fluorescence; based; Detection; Bacteria

The majority of the 147,000 sepsis cases seen by the NHS annually, are caused by bacterial infections. There is a pressing need for rapid tools for detecting and identifying bacteria in patient samples. Of the £830 M in sepsis treatment costs paid by the NHS and the USD $20 billion by American hospitals, 25% can be saved by reducing time to diagnosis. In this project, we aim to deliver a novel quantum optics inspired (QPS) device which detects bacteria labelled with new fluorescent carbon nanomaterials in patient samples within 5 mins or less. This system aims to detect the actual cause (bacteria) of the infection as opposed to bio-markers targeted by other Point of Care devices. Our approach will enable the appropriate prescription of anti-biotics and therefore limit the abuse of broad spectrum agents. This project will place FluoretiQ and University of Bristol in a strong position to attract the follow-on support necessary to commercialise the combined technology diagnostic solution. It also provides FluoretiQ the opportunity to leverage its QPS system to service a new application which would otherwise not be possible with current resources. Keywords: Rapid Detection of Bacteria, Sepsis, Bacteria Sensor

NHS每年发现的147，000例败血症病例中，大多数是由细菌感染引起的。迫切需要用于检测和鉴定患者样品中的细菌的快速工具。在NHS支付的8.3亿英镑败血症治疗费用和美国医院支付的200亿美元中，25%可以通过缩短诊断时间来节省。在这个项目中，我们的目标是提供一种新的量子光学启发（QPS）设备，该设备可以在5分钟或更短的时间内检测患者样本中标记有新荧光碳纳米材料的细菌。该系统旨在检测感染的实际原因（细菌），而不是其他护理点设备所针对的生物标记物。我们的方法将使抗生素的适当处方，从而限制广谱药物的滥用。该项目将使FluoretiQ和布里斯托大学处于有利地位，以吸引必要的后续支持，使组合技术诊断解决方案商业化。它还为FluoretiQ提供了利用其QPS系统为新应用程序提供服务的机会，而这在现有资源下是不可能的。关键词：细菌快速检测，脓毒症，细菌传感器

项目成果

Synthesis of 2-deoxy mucin-type O-glycan analogues as biological probes.

合成 2-脱氧粘蛋白型 O-聚糖类似物作为生物探针。

• DOI: 10.1016/j.carres.2022.108542
• 发表时间: 2022
• 期刊: Carbohydrate research
• 影响因子: 3.1
• 作者: Johnson SE

Green fluorescent carbon dots as targeting probes for LED-dependent bacterial killing

• DOI: 10.1002/nano.202100183
• 发表时间: 2022-03-01
• 期刊: NANO SELECT
• 作者: Samphire，Jennifer;Takebayashi，Yuiko;Galan，M. Carmen
• 通讯作者: Galan，M. Carmen

Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies.

• DOI: 10.3389/fonc.2021.743814
• 发表时间: 2021
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: Harland A;Liu X;Ghirardello M;Galan MC;Perks CM;Kurian KM
• 通讯作者: Kurian KM