Rapid Fluorescence-based Detection of Bacteria using Quantum Optics

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The majority of the 147,000 sepsis cases seen by the NHS annually, are caused by bacterial infections. There is a pressing need for rapid tools for detecting and identifying bacteria in patient samples. Of the £830 M in sepsis treatment costs paid by the NHS and the USD $20 billion by American hospitals, 25% can be saved by reducing time to diagnosis. In this project, we aim to deliver a novel quantum optics inspired (QPS) device which detects bacteria labelled with new fluorescent carbon nanomaterials in patient samples within 5 mins or less. This system aims to detect the actual cause (bacteria) of the infection as opposed to bio-markers targeted by other Point of Care devices. Our approach will enable the appropriate prescription of anti-biotics and therefore limit the abuse of broad spectrum agents. This project will place FluoretiQ and University of Bristol in a strong position to attract the follow-on support necessary to commercialise the combined technology diagnostic solution. It also provides FluoretiQ the opportunity to leverage its QPS system to service a new application which would otherwise not be possible with current resources. Keywords: Rapid Detection of Bacteria, Sepsis, Bacteria Sensor