Utilising the Vibro-Impact Self-Propulsion Technique for Gastrointestinal Endoscopy

利用振动冲击自推进技术进行胃肠内窥镜检查

• 批准号: EP/R043698/1
• 负责人: Yang Liu
• 金额: $ 4.04万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FR043698%2F1
• 关键词: Utilising; Vibro; Impact; Self; Propulsion

Gastrointestinal (GI) disease is the third most common cause of death, the leading cause of cancer death, and the most common cause of hospital admission. The burden of GI disease in the UK is heavy for patients, the National Health Service (NHS), and the economy. Endoscopy plays a vital role in the diagnosis of GI disorders, and the demand for GI endoscopy has doubled in the past 5 years, with on-going growth of 6.5% per annum predicted by the NHS (Scoping the Future, Cancer Research UK, 2015).Since its introduction into clinical practice 15 years ago, capsule endoscopy has become established as the primary modality for examining the surface lining of the small intestine, an anatomical site previously considered to be inaccessible to clinicians. However, its reliance on peristalsis for passage through the intestine leads to significant limitations, in particular due to the unpredictable and variable locomotion velocity. Significant abnormalities may be missed, due to intermittent high transit speeds that lead to incomplete visualisation of the intestinal surface. Furthermore, each case produces up to 100,000 still images, from which video footage is generated, taking between 30 and 90 minutes for the clinician to examine in its entirety. The procedure is therefore considered both time-consuming and burdensome for clinicians.There is, therefore, in GI endoscopic practice a desperate need for new modalities that are safe, painless, accurate, reliable and disposable, and which require minimal training for practitioners. This project attempts to find the way to adapt the vibro-impact self-propulsion technique into capsule endoscopy, and to explore the feasibility of innovation for the next generation of endoscopy: the self-propelled capsule endoscopy. Dr Yang Liu is an early-career researcher with a research background in applied dynamics and control, who has focused on developing this self-propulsion technique for different engineering systems. The nature of his applied research urges him to transfer any research findings into practical applications, and capsule endoscopy is one of the core deliverable areas for which the technique can make a revolutionary breakthrough. This requires to equip Dr Liu with the necessary clinical experience and knowledge to transfer his engineering research technologies into the healthcare domain. Therefore, the aims of the proposed discipline hop are: (1) to widen his healthcare technologies' expertise and clinic experience, (2) to embed his research into healthcare technologies, (3) to initiate the development work of the self-propelled capsule endoscopy, and (4) to build a long-lasting working relationship with clinicians, initially in the local NHS hospital, and later worldwide.The approach for Dr Liu to realize this ambitious goal is: 1) to undertake a 6 month discipline hop, learning, observing and being trained in the Endoscopy Department at the Royal Devon & Exeter NHS Foundation Trust; 2) to refine research questions and develop potential solutions; and 3) to fully understand the development cycle of implementing such technique in healthcare sector, including the key activities at the stages of Translational Development, Clinical Evaluation and Regulatory Approval, and Adoption and Diffusion.

胃肠道（GI）疾病是第三大最常见的死亡原因，是癌症死亡的主要原因，也是住院的最常见原因。在英国，胃肠道疾病的负担对患者、国民健康服务（NHS）和经济来说都很沉重。内窥镜检查在胃肠道疾病的诊断中起着至关重要的作用，在过去5年中，对胃肠道内窥镜检查的需求翻了一番，NHS预测每年将持续增长6.5%（Scoping the Future，Cancer Research UK，2015）自15年前引入临床实践以来，胶囊内窥镜检查已经被确立为用于检查小肠表面衬里的主要模式，小肠表面衬里是以前认为临床医生无法接近的解剖部位。然而，其对通过肠的蠕动的依赖导致显著的限制，特别是由于不可预测和可变的运动速度。由于间歇性的高传输速度导致肠表面的不完全可视化，可能会错过显著的异常。此外，每个病例产生多达100，000张静态图像，从中生成视频片段，临床医生需要30到90分钟才能进行完整检查。因此，对于临床医生来说，该过程既耗时又繁重，因此，在GI内窥镜实践中迫切需要安全、无痛、准确、可靠和一次性的新模式，并且需要对从业者进行最少的培训。本课题试图将冲击振动自推进技术应用于胶囊内窥镜，探索下一代内窥镜技术--自推进胶囊内窥镜的创新可行性。Yang Liu博士是一位具有应用动力学和控制研究背景的早期职业研究员，他专注于为不同的工程系统开发这种自推进技术。他的应用研究的性质促使他将任何研究成果转化为实际应用，而胶囊式内窥镜是该技术可以取得革命性突破的核心可交付领域之一。这需要为刘博士提供必要的临床经验和知识，以将他的工程研究技术转移到医疗保健领域。因此，建议的学科跳跃的目的是：（1）扩大其医疗技术的专业知识和临床经验，（2）将其研究嵌入医疗技术，（3）启动自走式胶囊内窥镜的开发工作，以及（4）与临床医生建立长期的工作关系，最初在当地NHS医院，刘博士实现这一宏伟目标的方法是：1）在皇家德文郡和埃克塞特NHS基金会信托的内窥镜部门进行为期6个月的学科跳跃，学习，观察和培训; 2）完善研究问题并开发潜在的解决方案;以及3）充分了解在医疗保健行业实施此类技术的开发周期，包括转化开发、临床评价和监管批准以及采用和推广阶段的关键活动。

项目成果

A survey of small bowel modelling and its applications for capsule endoscopy

• DOI: 10.1016/j.mechatronics.2022.102748
• 发表时间: 2022-05
• 期刊: Mechatronics
• 影响因子: 3.3
• 作者: Y. Liu;Jiyuan Tian;L. Manfredi;B. Terry;S. Prasad;I. Rahman;W. Marlicz;Anastasios Koulaouzidis

Dynamic analysis of a soft capsule robot self-propelling in the small intestine via finite element method

• DOI: 10.1007/s11071-023-08376-z
• 发表时间: 2023-04
• 期刊: Nonlinear Dynamics
• 影响因子: 5.6
• 作者: Jiyuan Tian;K. O. Afebu;Ze Wang;Y. Liu;S. Prasad

Fundamentals of Bowel Cancer for Biomedical Engineers.

• DOI: 10.1007/s10439-023-03155-8
• 发表时间: 2023-04
• 期刊: ANNALS OF BIOMEDICAL ENGINEERING
• 影响因子: 3.8
• 作者: Tian, Jiyuan;Afebu, Kenneth Omokhagbo;Bickerdike, Andrew;Liu, Yang;Prasad, Shyam;Nelson, Bradley J.
• 通讯作者: Nelson, Bradley J.

Finite element analysis of a self-propelled capsule robot moving in the small intestine

• DOI: 10.1016/j.ijmecsci.2021.106621
• 发表时间: 2021-06
• 期刊: International Journal of Mechanical Sciences
• 影响因子: 7.3
• 作者: Jiyuan Tian;Yang Liu;Junning Chen;Bingyong Guo;S. Prasad

Modelling of capsule-intestine contact for a self-propelled capsule robot via experimental and numerical investigation

• DOI: 10.1007/s11071-019-05061-y
• 发表时间: 2019-12-01
• 期刊: NONLINEAR DYNAMICS
• 影响因子: 5.6
• 作者: Guo, Bingyong;Liu, Yang;Prasad, Shyam
• 通讯作者: Prasad, Shyam