PNEUMACRIT: Preterm Neonate / neonatal Embedded Universal Microelectronic wearable Acquisition For Cardio Respiratory Intensive Therapy

PNEUMACRIT将提供革命性的多传感器可穿戴成像系统，为患有可能导致呼吸问题的婴儿和儿童的肺功能诊断提供信息。虽然呼吸支持，特别是机械通气，可以提高他们的存活率，但它也可能对脆弱的肺部造成严重伤害，导致慢性肺部疾病持续到成年。通过提供低成本的监测系统，PNEUMACRIT有可能提供婴儿呼吸衰竭的早期检测，这也将促进呼吸支持的优化。这将提供立竿见影的好处，并降低患者患长期呼吸系统疾病的风险。PNEUMACRIT追求在分析测量、嵌入柔性可打印可穿戴材料的微系统、信号处理和有机设备方面的突破，从电阻抗断层扫描（EIT）、心电图（ECG）和呼吸暂停监测产生的数据中获得多参数临床测量。EIT是一种非辐射、廉价的技术，使用小电流产生身体的横截面图像，可以促进实时动态监测肺通气，最近的研究表明，它在临床环境中对早产儿的通气监测是有效的。然而，为了最大限度地发挥其诊断潜力，这种EIT信息需要与其他非侵入性措施相结合。该项目中电极技术的进步将实现多地点记录，而无需物理互连和集成电源，为新一代诊断可穿戴设备打开大门。这种监测是至关重要的，因为每年全世界有数百万婴儿因肺部不成熟或传染病而患有呼吸衰竭。此外，标准肺功能测试不适用于婴儿和幼儿，直到他们足够大，能够积极配合指示（~ 7岁）。因此，PNEMACRIT将来也可以为这一年龄组提供有价值的肺功能信息。

PNEUMACRIT will provide a revolutionary multi sensor wearable imaging system that will inform lung function diagnosis for infants and children with conditions that can lead to respiratory problems. Although respiratory support, especially mechanical ventilation, can improve their survival, it may also cause severe injury to the vulnerable lungs, resulting in chronic pulmonary morbidity lasting into adulthood. PNEUMACRIT has the potential to provide early detection of respiratory failure in infants, by providing a low-cost monitoring system, which will also facilitate optimisation of the respiratory support. This will provide both immediate benefits and decrease the risk of patients developing long-term respiratory disorders. PNEUMACRIT pursues breakthroughs in analytical measurement, microsystems embedded in flexible printable wearable materials, signal processing, and organic devices, to produce multi-parameter clinical measurements obtained from the data produced from electrical impedance tomography (EIT), Electrocardiogram (ECG) and apnoea monitoring. EIT is a non-radiative, inexpensive technique that uses small electrical currents to produce cross sectional images of the body that can facilitate real time dynamic monitoring of lung aeration, and recent studies have shown that it is effective in monitoring aeration in preterm babies in a clinical setting. However, to maximise its diagnostics potential, this EIT information need to be combined with other non-invasive measures. Advances in electrode technologies within the project will enable multi-site recordings, without the need for physical interconnection and integrated power supplies, opening the door to a new generation of diagnostic wearables. Such monitoring is crucial because each year millions of babies across the world suffer from respiratory failure due to immaturity of the lung or infectious diseases. In addition, standard lung function tests are not suitable for use with babies and young children until they are old enough to actively co-operate with instructions (~age 7 years). Therefore, PNEMACRIT could, in future, provide valuable lung function information to this age group as well.