FOVEAL PHOTOCOAGULATION STUDY COORDINATING CENTER

建议的中心凹光凝研究是一项多中心的研究 黄斑下老年性变性(AMD)的治疗 新生血管损伤。该研究由两组随机对照组成 激光光凝治疗的试验和自然病史研究 眼睛没有资格参加选拔赛。符合视力的符合条件的AMD患者 随机试验的视力标准(20/80大于VA 超过20/320)将被分配到治疗或不治疗 新生血管病变。自然史研究的患者将患有AMD和 中心凹下新生血管病变，但视力超过20/80。 随机试验的目的是确定氪红是否 激光光凝可有效预防或延缓严重的失血。 黄斑中心凹下病变的AMD患者的视力：这些是否是新的 新生血管病变或中心凹下复发新生血管形成 对于黄斑中心凹外或Jextaveve病变，事先进行治疗。该计划的目的是 自然史研究是为了确定视力 患有AMD和中心凹下新生血管的眼睛恶化到20/80或更糟 患者首次临床表现后的胎膜 否则有资格参加随机试验。 这项研究将在十二个临床中心进行， 中心和眼底照片阅读中心；研究调查人员和 中心是那些在黄斑光凝方面合作的人 过去六年的研究(MPS)。 提交这项提案是为了获得协调中心的资金 用于多中心研究。协调中心的作用将是 与该中心在黄斑光凝研究中的作用类似， 和方法可以直接从MPS转移到拟议的 学习。协调中心的结构是建立在工作人员的基础上 为MPS开发的经验和系统。

The proposed Foveal Photocoagulation Study is a multicenter study of treatment for age-related degeneration (AMD) in eyes with subfoveal neovascular lesions. The study consists of two randomized controlled trials of laser photocoagulation treatment and a natural history study of eyes ineligible for the trials. Eligible AMD patients who meet the visual acuity criteria for the randomized trials (20/80 greater than VA greater than 20/320) will be assigned to treatment or to no treatment of the neovascular lesion. Natural history study patients will have AMD and a subfoveal neovascular lesion but visual acuity better than 20/80. The purpose of the randomized trials is to determine whether krypton red laser photocoagulation is effective in preventing or delaying severe loss of vision in AMD patients who have subfoveal lesions, whether these are new neovascular lesions or recurrent neovasculrization subfoveally following prior treatment for extrafoveal or jextafoveal lesions. The purpose of the natural history study is to determine the rate at which visual acuity deteriorates to 20/80 or worse in eyes with AMD and subfoveal neovascular membranes after initial clinical presentation of patients who would otherwise be eligible for the randomized trials. This study will be carried out in twelve Clinical Center, a Coordinating Center, and a Fundus Photograph Reading Center; the study investigators and centers are those who have collaborated in the Macular Photocoagulation Study (MPS) over the past six years. This proposal is submitted to obtain funding for the Coordinating Center for the multicenter study. The role of the Coordinating Center will be similar to the role of that center in the Macular Photocoagulation Study, and methodology is directly transferrable from the MPS to the proposed study. The Coordinating Center has been structured to build on the staff experiences and systems developed for the MPS.