MACULAR PHOTOCOAGULATION STUDY COORDINATING CENTER

黄斑光凝研究协调中心

• 批准号: 3551489
• 负责人: Barbara Snyder Hawkins
• 金额: $ 2.56万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3551489
• 关键词: aging; cooperative study; disease /disorder prevention /control; eye surgery; fovea centralis retinae; human subject; human therapy evaluation; lasers; photocoagulation therapy; retina degeneration; vision disorders

The proposed Foveal Photocoagulation Study is a multicenter study of treatment for age-related degeneration (AMD) in eyes with subfoveal neovascular lesions. The study consists of two randomized controlled trials of laser photocoagulation treatment and a natural history study of eyes ineligible for the trials. Eligible AMD patients who meet the visual acuity criteria for the randomized trials (20/80 greater than VA greater than 20/320) will be assigned to treatment or to no treatment of the neovascular lesion. Natural history study patients will have AMD and a subfoveal neovascular lesion but visual acuity better than 20/80. The purpose of the randomized trials is to determine whether krypton red laser photocoagulation is effective in preventing or delaying severe loss of vision in AMD patients who have subfoveal lesions, whether these are new neovascular lesions or recurrent neovasculrization subfoveally following prior treatment for extrafoveal or jextafoveal lesions. The purpose of the natural history study is to determine the rate at which visual acuity deteriorates to 20/80 or worse in eyes with AMD and subfoveal neovascular membranes after initial clinical presentation of patients who would otherwise be eligible for the randomized trials. This study will be carried out in twelve Clinical Center, a Coordinating Center, and a Fundus Photograph Reading Center; the study investigators and centers are those who have collaborated in the Macular Photocoagulation Study (MPS) over the past six years. This proposal is submitted to obtain funding for the Coordinating Center for the multicenter study. The role of the Coordinating Center will be similar to the role of that center in the Macular Photocoagulation Study, and methodology is directly transferrable from the MPS to the proposed study. The Coordinating Center has been structured to build on the staff experiences and systems developed for the MPS.

拟议的中心凹光凝研究是一项多中心研究， 治疗具有中心凹下的眼睛中的年龄相关性变性（AMD） 新生血管病变 该研究包括两个随机对照组， 激光光凝治疗的试验和 眼睛不适合试验。 符合视力要求的合格AMD患者 随机试验的视力标准（20/80大于VA大于 超过20/320）将被分配到治疗或不治疗 新生血管病变 自然史研究患者将患有AMD， 中心凹下新生血管病变，但视力优于20/80。 随机试验的目的是确定氪红 激光光凝可有效预防或延迟严重的损失 有黄斑下病变的AMD患者的视力，无论这些是新的 新生血管病变或复发性新生血管形成 对中心凹外或中心凹外病变的既往治疗。 的目的 自然史研究是为了确定视力 在患有AMD和黄斑下新生血管的眼睛中恶化至20/80或更差 膜后，最初的临床表现的患者， 否则将有资格参加随机试验。 本研究将在12个临床中心进行， 中心和眼底照片阅读中心;研究者和 中心是那些在黄斑光凝术中合作的中心， 在过去的六年里，MPS研究。 提交本提案是为了为协调中心获得资金 进行多中心研究。 协调中心的作用将是 与黄斑光凝研究中该中心的作用相似， 和方法可直接从MPS转移到建议的 study. 协调中心的结构是以工作人员为基础， 为MPS开发的经验和系统。