TRANSFUSION TRIAL TO PREVENT PLATELET ALLOIMMUNIZATIONS

预防血小板同种免疫的输血试验

• 批准号: 3553343
• 负责人: WENDELL F ROSSE
• 金额: $ 8.42万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553343
• 关键词: antibody specificity; antigen presenting cell; blood donor; blood filtration; cooperative study; epidemiology; histocompatibility antigens; homologous transplantation; human subject; human therapy evaluation; immunofluorescence technique; leukocyte antigen typing; platelet transfusion; platelets; radiation immunosuppression; radioimmunoassay; ultraviolet radiation

Alloimmunization to antigens on platelets is one of the most severe limiting factors in platelet transfusion. In this application to become a member of a cooperative trial for the prevention of alloimmunization, we propose two strategies which might limit alloimmunization from this source in patients treated for acute non-lymphocytic leukemia: 1. selection of platelet donors by matching HLA antigens, particularly the so-called "public" antigens; 2. removal of leukocytes from platelet products by filtration. In a cooperative study, we would be able to implement other strategies if they were selected. We also propose methods for following the development of alloimmunization to both HLA and platelet-specific antigens and for determining the epidemiology of alloimmunization.

对血小板抗原的同种免疫是最严重的一种